Table 6.3Evidence profile for bedtime doses of oral diazepam compared with placebo in children with spasticity of different severities; treatment acceptability assessment

Number of studiesNumber of participantsEffectQuality
DiazepamPlaceboRelative

(95% CI)
Absolute

(95% CI)
Child's disposition during activities of daily living at 15–20 days, bedtime dose of diazepam (better indicated by higher values)
1 study (Mathew 2005a)59a55b-MD 5.93 higher (5.41 to 6.45 higher)Moderate
Burden of caring for the child on the family at 15–20 days, bedtime dose of diazepam (better indicated by higher values)
1 study (Mathew 2005a)59c55d-MD 7.31 higher (6.78 to 7.84 higher)Moderate
Child's behavioural profile at 15–20 days, bedtime dose of diazepam (better indicated by higher values)
1 study (Mathew 2005a)59e55f-MD 7.35 higher (6.74 to 7.96 higher)Moderate

CI confidence interval, MD mean difference, SD standard deviation

*

Calculated by the NCC-WCH

a

Mean change in score 6.31 SD 1.94

b

Mean change in score 0.38 SD 0.62

c

Mean change in score 7.75 SD 1.98

d

Mean change in score 0.44 SD 0.66

e

Mean change in score 8.17 SD 2.14

f

Mean change in score 0.82 SD 1.07

See the complete GRADE Table K.6.3 which accompanies this abbreviated version.

Mean change in score 6.31 SD 1.94

Mean change in score 0.38 SD 0.62

Mean change in score 7.75 SD 1.98

Mean change in score 0.44 SD 0.66

Mean change in score 8.17 SD 2.14

Mean change in score 0.82 SD 1.07

From: 6, Oral drugs

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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