Table K.4.9Evidence profile for strengthening programmes (progressive resistive exercises) compared with usual care in children with unilateral or bilateral spasticity; quality of life

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsStrengtheningUsual careRelative

(95% CI)
Absolute
Self-perception of functional competence at 8 weeks (composite score/25) (change from baseline) (Better indicated by higher values)
1 study (Unger 2006)randomised trialsserious1no serious inconsistencyno serious indirectnessserious2none243134-MD 0.1 lower*5Low
Self-perception of body image at 8 weeks (composite score/25) (change from baseline) (Better indicated by higher values)
1 study (Unger 2006)randomised trialsserious1no serious inconsistencyno serious indirectnessserious2none246137-MD 2.9 higher*8Low
Self-perception (Global self-worth) at 18 weeks (score 0 to 4) (Better indicated by lower values)
1 study (Dodd 2004)randomised trialsserious1no serious inconsistencyno serious indirectnessserious2none109610-MD 0.02 higher*11Low

CI confidence interval, MD mean difference

*

Calculated by the NCC-WCH

1

Allocation concealment details unclear

2

Total population less than 400, 95% confidence interval not calculable

3

Pre-training score = 19.9 (3.4), Post-training score = 21.3 (3.3)

4

Pre-training score = 19.0 (3.2), Post-training score = 20.5 (3.3)

5

p = NS reported

6

Pre-training score = 23.9 (4.1), Post-training score = 25.9 (3.4)

7

Pre-training score = 23.2 (4.6), Post-training score = 22.3 (4.7)

8

p < 0.05 reported

9

Baseline score = 3.41 (0.38), Follow up at 18 weeks = 3.57 (0.45)

10

Baseline score = 3.27 (0.52), Follow up at 18 weeks = 3.41 (0.49)

11

p=NS reported

Calculated by the NCC-WCH

Allocation concealment details unclear

Total population less than 400, 95% confidence interval not calculable

Pre-training score = 19.9 (3.4), Post-training score = 21.3 (3.3)

Pre-training score = 19.0 (3.2), Post-training score = 20.5 (3.3)

p = NS reported

Pre-training score = 23.9 (4.1), Post-training score = 25.9 (3.4)

Pre-training score = 23.2 (4.6), Post-training score = 22.3 (4.7)

p < 0.05 reported

Baseline score = 3.41 (0.38), Follow up at 18 weeks = 3.57 (0.45)

Baseline score = 3.27 (0.52), Follow up at 18 weeks = 3.41 (0.49)

p=NS reported

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.