Table K.4.5Evidence profile for constraint-induced movement therapy versus bimanual therapy in children and young people with spasticity; functioning assessment

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsConstraint-induced movement therapyBimanual trainingRelative

(95% CI)
Absolute
Assisting Hand Assessment (AHA) at 3 weeks (change from baseline) (Better indicated by higher values)
1 study (Sakzewski 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none3131-MD 1.2 higher (1.2 lower to 3.5 higher)Moderate
AHA at 26 weeks (change from baseline) (Better indicated by higher values)
1 study (Sakzewski 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none2830-MD 0.7 lower (3.1 lower to 10.3 higher)Moderate
Melbourne Assessment of Unilateral Upper Limb Function (MAUULF) at 3 weeks (change from baseline) (Better indicated by higher values)
1 study (Sakzewski 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none3131-MD 1.8 higher (0.3 lower to 4.0 higher)Moderate
MAUULF at 26 weeks (change from baseline) (Better indicated by higher values)
1 study (Sakzewski 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none2830-MD 4.4 higher (2.2 to 6.7 higher)Moderate

CI confidence interval, MD mean difference

1

Total population less than 400

Total population less than 400

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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