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Table 12Strength of evidence for health outcomes

OutcomeGroupNumber of StudiesRisk of BiasConsistencyDirectnessPrecisionStrength of Evidence
Key Question 1: Quality of lifeAll interventions vs. control2 RCTsHighUnknownDirectImpreciseInsufficient
System-level interventions vs. control1HighUnknownDirectImpreciseInsufficient
Regimen-related intervention vs. control0--------Insufficient
Patient-related intervention vs. control0--------Insufficient
Adverse event management intervention vs. control1HighUnknownDirectImpreciseInsufficient
Key Question 1: Mortality & MorbidityAll interventions vs. control0--------Insufficient
System-level interventions vs. control0--------Insufficient
Regimen-related intervention vs. control0--------Insufficient
Patient-related intervention vs. control0--------Insufficient
Adverse event management intervention vs. control0--------Insufficient
Key Question 3: HarmsAll interventions vs. control2 RCTsHighUnknownUnknownUnknownInsufficient
System-level interventions vs. control0--------Insufficient
Regimen-related intervention vs. control0--------Insufficient
Patient-related intervention vs. control0--------Insufficient
Adverse event management intervention vs. control2HighUnknownUnknownUnknownInsufficient

DOT = directly observed therapy; QOL = quality of life; RCT = randomized controlled trial; vs. = versus

No reported adverse events related to intervention without further detail. Thus, the consistency, directness, and precision of the outcomes are unknown.

No reported adverse events related to intervention without further detail. Thus, the consistency, directness, and precision of the outcomes are unknown.

From: Summary and Discussion

Cover of Interventions to Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness
Interventions to Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 91.
Sun X, Patnode CD, Williams C, et al.

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