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Cherry MG, Greenhalgh J, Osipenko L, et al. The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation. Southampton (UK): NIHR Journals Library; 2012 Nov. (Health Technology Assessment, No. 16.43.)

Cover of The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation

The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation.

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Appendix 1Literature search strategies

TABLE 35Search strategy and search results

DatabaseYearsSearch strategyReferences identified
MEDLINE1950 to May 2011 (Week 18)See below920
EMBASE1980 to May 2011 (Week 18)See below1065
The Cochrane Library 2011a2011105

(CENTRAL, CDSR, DARE, HTA database, NHS EED)
Total references identified2090
Duplicates762
Total1328
a

Includes CENTRAL, CDSR, DARE, HTA database and NHS EED.

TABLE 36Search strategy: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations 1948 to week 2 April 2011

SearchesResults
1exp Anemia, Sickle Cell/15,785
2(sickle-cell or sickle cell).mp.18,041
3drepanocytosis.mp.189
4(sickling and (blood or plasma)).tw.377
5exp Hemoglobin, Sickle/2513
6(hemoglobin s or haemoglobin s).tw.1095
7(hemoglobin sc disease or haemoglobin sc disease).tw.142
8exp Stroke/63,305
9((isc?emic or apoplectic) adj5 (event or events or insult or attack$)).tw.16,197
10(stroke or poststroke or post-stroke or cerebrovasc$ or brain vasc$ or cerebral vasc$ or cva$ or apoplex$ or isch?emi$attack$ or tia$1 or neurologic$deficit$ or SAH or AVM).tw.161,386
11(cerebrovascular adj (accident$ or infarction$ or insult$)).tw.4499
12((brain$ or cerebr$ or cerebell$ or cortical or vertebrobasilar or hemispher$ or intracran$ or intracerebral or infratentorial or supratentorial or MCA or anterior circulation or posterior circulation or basal ganglia) adj5 (isch?emi$ or infarct$ or thrombo$ or emboli$ or occlus$ or hypox$ or vasospasm or obstruction or vasculopathy)).tw.71,283
13((brain$ or cerebr$ or cerebell$ or intracerebral or intracran$ or parenchymal or intraventricular or infratentorial or supratentorial or basal gangli$ or subarachnoid or putaminal or putamen or posterior fossa) adj5 (haemorrhage$ or hemorrhage$ or haematoma$ or hematoma$ or bleed$)).tw.39,369
14((brain or intracranial or basal ganglia or lenticulostriate) adj5 (vascular adj5 (disease$ or disorder or accident or injur$ or trauma$ or insult or event))).tw.779
15exp aphasia/or anomia/or hemiplegia/or hemianopsia/or exp paresis/or deglutition disorders/or dysarthria/or pseudobulbar palsy/or muscle spasticity/43,818
16exp Brain Ischemia/or exp Cerebral Hemorrhage/or exp Cerebral Infarction/or exp Cerebrovascular Trauma/or exp Hypoxia-Ischemia, Brain/94,307
17or/1–719,127
18or/8–16302,677
1917 and 181020
20limit 19 to (english language and humans)934

TABLE 37Search strategy: EMBASE 1980 to week 17 2011

SearchesResults
1exp sickle cell/1163
2(sickle cell or sickle-cell).mp.21,977
3drepanocytosis.mp.218
4(sickling and (blood or plasma)).tw.417
5exp hemoglobin S/2707
6(hemoglobin s or haemoglobin s).tw.1092
7(hemoglobin sc disease or haemoglobin sc disease).tw.139
8exp STROKE/98,235
9((isc?emic or apoplectic) adj5 (event or events or insult or attack$)).tw.20,249
10(stroke or poststroke or post-stroke or cerebrovasc$ or brain vasc$ or cerebral vasc$ or cva$ or apoplex$ or isch?emi$attack$ or tia$1 or neurologic$deficit$ or SAH or AVM).tw.207,204
11(cerebrovascular adj (accident$ or infarction$ or insult$)).tw.5591
12((brain$ or cerebr$ or cerebell$ or cortical or vertebrobasilar or hemispher$ or intracran$ or intracerebral or infratentorial or supratentorial or MCA or anterior circulation or posterior circulation or basal ganglia) adj5 (isch?emi$ or infarct$ or thrombo$ or emboli$ or occlus$ or hypox$ or vasospasm or obstruction or vasculopathy)).tw.89,204
13((brain$ or cerebr$ or cerebell$ or intracerebral or intracran$ or parenchymal or intraventricular or infratentorial or supratentorial or basal gangli$ or subarachnoid or putaminal or putamen or posterior fossa) adj5 (haemorrhage$ or hemorrhage$ or haematoma$ or hematoma$ or bleed$)).tw.48,392
14((brain or intracranial or basal ganglia or lenticulostriate) adj5 (vascular adj5 (disease$ or disorder or accident or injur$ or trauma$ or insult or event))).tw.960
15exp aphasia/or anomia/or hemiplegia/or hemianopsia/or exp paresis/or deglutition disorders/or dysarthria/or pseudobulbar palsy/or muscle spasticity/71,779
16*brain ischemia/or *brain infarction/43,502
17or/1–723,021
18or/8–16387,369
1917 and 181546
20limit 19 to (human and English language)1224
21limit 20 to embase1072

TABLE 38Search strategy: CENTRAL first quarter 2011, CDSR 2005 to April 2011, DARE second quarter 2011, HTA database second quarter 2011, NHS EED second quarter 2011

SearchesResults
1Hemoglobin sickle.mp.16
2sickle cell.mp.729
3(sickled or sickling).mp.52
4drepanocytosis.mp2
5(hemoglobin sc or haemoglobin sc).mp.27
6exp sickle cell anemia/274
7exp brain ischemia/or exp cerebrovascular accident/or exp brain infarction/or exp cerebrovascular trauma/or exp hypoxia-ischemia, brain/3633
8(stroke or poststroke or post-stroke or cerebrovasc* or brain vasc* or cerebral vasc* or cva* or apoplex* or ischemi* attack* or ischaemi* attack* or tia* or neurologic* deficit* or SAH or AVM).mp.22,884
9or/1–6736
107 or 823,271
119 and 10105

Includes CENTRAL, CDSR, DARE, HTA database and NHS EED.

© 2012, Crown Copyright.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK115671
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