This figure depicts how treatments for RLS (KQ1) may contribute to health outcomes in the target population in light of potential modifiers of effect (KQ3) such as age, gender, sex, RLS severity, etiology, comorbidities, iron status, pregnancy and end-stage renal disease. In general, the figure illustrates how treatments for RLS may result in primary outcomes such as change in disease severity and impact on function and secondary outcomes such as quality of life outcomes and patient-reported sleep outcomes. Also, adverse events may occur at any point after the treatment is received (KQ2).

Figure 1Analytical framework

KQ = Key Question; RLS = restless legs syndrome

From: Introduction

Cover of Treatment for Restless Legs Syndrome
Treatment for Restless Legs Syndrome [Internet].
Comparative Effectiveness Reviews, No. 86.
Wilt TJ, MacDonald R, Ouellette J, et al.

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