Table 53Summary of the strength of evidence for the effectiveness of combination interventions versus an active treatment (Key Question 1)

OutcomeComparison (# Studies)Strength of EvidenceSummary
Pain reduction–VASMetoclopramide + DHE vs. butorphanol (1 RCT)InsufficientNo significant difference between groups
(MD = −5.00; 95% CI: −19.98, 9.98)
Pain reduction–VASMetoclopramide + DHE vs. meperidine + hydroxyzine (1 RCT)InsufficientSignificant effect in favor of metoclopramide + DHE; (MD = −22.00; 95%CI: −36.66, −7.34)
Pain reduction–VASProchlorperazine + DHE vs. prochlorperazine (1 RCT)InsufficientNo significant difference between groups
(MD = 5.00; 95% CI: −18.96, 28.96)
Pain reduction–VASMetoclopramide + pethidine vs. metoclopramide (1 RCT)InsufficientNo significant difference between groups
(MD = 0.00; 95% CI: −8.47, 8.47)
Pain reduction–VASMetoclopramide + pethidine vs. pethidine (1 RCT)InsufficientSignificantly favors metoclopramide + pethidine
(MD = −10.0; 95% CI: −19.2, −0.79)
Pain reduction–VASMetoclopramide + MgSO4 vs metoclopramide (1 RCT)InsufficientNo significant difference between groups
(MD = 16.00; 95% CI: −1.58, 33.58)
Pain reduction–VASMetoclopramide + DHE vs. valproate (1 RCT)InsufficientNo significant difference between groups
(RR = 1.10; 95%CI: 0.61,1.99)
Pain reduction–VASMetoclopramide + chlorpromazine vs. metoclopramide + sumatriptan (1 RCT)InsufficientNo significant difference between groups
(MD = 9.00; 95% CI: −4.04, 22.04)
Pain reduction–VASMetoclopramide + DHE vs. ketorolac (1 RCT)InsufficientSignificant effect in favor of metoclopramide + DHE; (MD = −30.0; 95% CI: −57.72, −2.28)
Pain reduction–VASMetoclopramide + DHE vs metoclopramide + dexamethasone (1 RCT)InsufficientNo significant difference between groups
(RR = 0.95; 95% CI: 0.61, 1.49)

CI = confidence interval; DHE = dihydroergotamine; MD = mean difference; MgSO4 = magnesium sulfate; RCT = randomized controlled trial; RR = risk ratio; VAS = visual analog scale

From: Summary and Discussion

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
Comparative Effectiveness Reviews, No. 84.
Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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