Table 49Summary of the strength of evidence for the effectiveness of DHE versus placebo or an active treatment (Key Question 1)

OutcomeComparison (# Studies)Strength of EvidenceSummary
Pain intensity- VASDHE vs. meperidine (1 RCT)InsufficientNo significant difference between groups
(MD = −2.20; 95% CI: −10.03, 14.43)
Pain intensity- VASDHE vs. diclofenac (1 RCT)InsufficientNo significant difference between groups
(MD = −13.00; 95% CI: −28.52, 2.52)
Headache relief (1 hr)DHE vs. sumatriptan (1 RCT)InsufficientSignificant effect in favor of sumatriptan
(RR = 0.73; 95% CI: 0.61, 0.86)
Headache relief (2 hrs)DHE vs. sumatriptan (1 RCT)InsufficientSignificant effect in favor of sumatriptan
(RR = 0.86; 95% CI: 0.76, 0.96)
Headache relief (3 hrs)DHE vs. sumatriptan (1 RCT)InsufficientNo significant difference between groups
(RR = 0.96; 95% CI: 0.88, 1.04)
Headache relief (4 hrs)DHE vs. sumatriptan (1 RCT)InsufficientNo significant difference between groups
(RR = 1.03; 95% CI: 0.93, 1.13)
Headache relief (24 hrs)DHE vs. sumatriptan (1 RCT)InsufficientSignificant effect in favor of DHE
(RR = 1.17; 95% CI: 1.05, 1.30)
Headache recurrenceDHE vs. sumatriptan (1 RCT)InsufficientSignificant effect in favor of DHE
(RR = 0.39; 95% CI: 0.26, 0.59)
Pain responseLysine acetylsalicylic acid vs. DHE (1 RCT)InsufficientSignificant effect in favor of lysine acetylsalicylic acid;
(RR = 1.92; 95% CI: 1.10, 3.36)
Change in pain- VASChlorpromazine vs. DHE (1 RCT)InsufficientSignificant effect in favor of chlorpromazine
(MD = −40.0; −47.12, −32.88)
Headache reliefChlorpromazine vs. DHE (1 RCT)InsufficientNo significant difference between groups
(RR = 1.44; 95% CI: 0.59, 3.56)

CI = confidence interval; DHE = dihydroergotamine; MD = mean difference; RCT = randomized controlled trial; RR = risk ratio; VAS = visual analog scale

From: Summary and Discussion

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
Comparative Effectiveness Reviews, No. 84.
Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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