Table 5Pooled Effect Sizes for Various Outcomes at 6–18 Months Post Baseline

OutcomeLocationEffect Size (95% CI)*Number of TrialsI2 (%)
ADLU.S.0.19 (0.06 to 0.33)613.8
Non-U.S.0.07 (−0.01 to 0.14)80.0
All0.10 (0.04 to 0.17)140.0
IADLU.S.0.20 (−0.04 to 0.45)459.1
Non-U.S.0.05 (−0.08 to 0.18)638.2
All0.10 (−0.01 to 0.22)1050.5
ADL/IADL**U.S.0.19 (0.00 to 0.38)656.8
Non-U.S.0.04 (−0.03 to 0.11)1117.4
All0.09 (0.01 to 0.16)1742.3
HospitalizationsU.S.1.00 (0.87 to 1.15)70.0
Non-U.S.0.90 (0.78 to 1.03)958.3
All0.93 (0.84 to 1.03)1642.2
InstitutionalizationsU.S.0.94 (0.76 to 1.18)70.0
Non-U.S.1.01 (0.80 to 1.27)120.0
All0.98 (0.83 to 1.15)190.0
MortalityU.S.0.89 (0.78 to 1.02)195.7
Non-U.S.0.93 (0.81 to 1.07)310.0
All0.91 (0.82 to 1.00)500.0
*

ADL, IADL, and ADL/IADL are continuous outcomes, and any effect size greater than 0 indicates the intervention had a favorable effect. Hospitalizations, institutionalizations, and mortality are dichotomous outcomes, and any effect size greater than 1 indicates the intervention had a favorable effect.

**

ADL/IADL as an outcome included, in order of preference, combined measures of ADL and IADL, IADL alone, and ADL alone.

Abbreviations: ADL=activities of daily living; CI=confidence interval; IADL=instrumental activities of daily living; US=United States.

From: 2, Results

Cover of Challenges in Synthesizing and Interpreting the Evidence From a Systematic Review of Multifactorial Interventions to Prevent Functional Decline in Older Adults
Challenges in Synthesizing and Interpreting the Evidence From a Systematic Review of Multifactorial Interventions to Prevent Functional Decline in Older Adults [Internet].
Evidence Syntheses/Technology Assessments, No. 94.
Lin JS, Whitlock EP, Eckstrom E, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.