Table 1Summary of Performed Assays

PubChem AIDAssay NameTested/ActiveNon-MLSMR Compounds TestedPurchased Compounds Tested/ActiveSynthesized Compounds Tested/Active
485348Primary LRH1 3X %INH60/196019/541/14
488782LRH1 Dose Response (Aromatase)16/13165/511/8
488779SF1 3X %INH (Lumi Reporter)60/36019/241/1
488780SF1 Dose Response16/0165/011/0
488775VP16 Fold Change59/95919/140/8
488769QPCR Assay(mRNA Fold change: Haptoglobin; SAA1; SAA4)2/221/11/1
504928MTT Assay (Breast Cancer Cell Lines)1/1110
504933Star INH Assay2/2220
504934Nuclear Receptor Profiling1/1110
488781Summary AID----

From: Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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