FIGURE 8-6. Genetic regulation of longevity in mice stratified by cause of death.

FIGURE 8-6Genetic regulation of longevity in mice stratified by cause of death

Male or female mice that inherit the C57BL/6 (maternal) and C3H (paternal) alleles at D12Mit167 (light gray bars) are longer lived than their siblings that inherit the BALB plus C3H combination. The “effect size” shown at the right represents that difference in mean longevity between mice in the two genetically different groups, with (**) = p < 0.01 and (*) = p < 0.05 by t-test. Similar effect sizes are seen for mice dying of cancer or of non-neoplastic illnesses (“benign”), and among the cancer deaths the genetic effect is similar for deaths due to lymphoma and hepatoma. The genetic effect on longevity seems to be minimal, however, for mice dying of fibrosarcoma. Bars show means plus standard errors. SOURCE: Miller et al. (unpublished results).

From: 8, Biomarkers and the Genetics of Aging in Mice

Cover of Cells and Surveys
Cells and Surveys: Should Biological Measures Be Included in Social Science Research?
National Research Council (US) Committee on Population; Finch CE, Vaupel JW, Kinsella K, editors.
Washington (DC): National Academies Press (US); 2001.
Copyright © 2001, National Academy of Sciences.

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