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Wang D, Bayliss S, Meads C. Palivizumab for Immunoprophylaxis of Respiratory Syncytial Virus (RSV) Bronchiolitis in High-Risk Infants and Young Children: Systematic Review and Additional Economic Modelling of Subgroup Analyses. Southampton (UK): NIHR Journals Library; 2011 Jan. (Health Technology Assessment, No. 15.5.)

Cover of Palivizumab for Immunoprophylaxis of Respiratory Syncytial Virus (RSV) Bronchiolitis in High-Risk Infants and Young Children: Systematic Review and Additional Economic Modelling of Subgroup Analyses

Palivizumab for Immunoprophylaxis of Respiratory Syncytial Virus (RSV) Bronchiolitis in High-Risk Infants and Young Children: Systematic Review and Additional Economic Modelling of Subgroup Analyses.

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Appendix 1Literature search strategies

Clinical effectiveness

Database: Cochrane Library (Wiley) 2009 Issue 3

#1.

respiratory next syncytial

#2.

rsv

#3.

bronchiolitis

#4.

MeSH descriptor Bronchiolitis, Viral, this term only

#5.

MeSH descriptor Respiratory Syncytial Virus, Human, this term only

#6.

(#1 OR #2 OR #3 OR #4 OR #5)

#7.

immunoprophylaxis

#8.

monoclonal next _ntibody*

#9.

MeSH descriptor Antibodies, Monoclonal explode all trees

#10.

palivizumab

#11.

synagis

#12.

(#7 OR #8 OR #9 OR #10 OR #11)

#13.

(#6 AND #12)

#14.

<nothing>, from 2007 to 2009

#15.

(#13 AND #14)

Database: Ovid MEDLINE® In-Process & Other Non-Indexed Citations 3 August 2009

  1. respiratory syncytial virus.mp.
  2. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  3. monoclonal antibod$.mp.
  4. synagis.mp.
  5. exp Immunotherapy/or immunoprophylaxis.mp.
  6. or/1-2
  7. or/3-6
  8. 7 and 8
  9. limit 9 to yr=“2007 – 2009”

Database: Ovid MEDLINE® 1950 to week 4 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. monoclonal _ntibody$.mp.
  6. exp Antibodies, Monoclonal/
  7. synagis.mp.
  8. exp Immunotherapy/or immunoprophylaxis.mp.
  9. or/5-9
  10. 4 and 10
  11. (systematic adj review$).tw.
  12. (data adj synthesis).tw.
  13. (published adj studies).ab.
  14. (data adj extraction).ab.
  15. comment.pt.
  16. letter.pt.
  17. editorial.pt.
  18. animal/
  19. human/
  20. not (21 and 22)
  21. 11 not (18 or 19 or 20 or 23)
  22. or/12-17
  23. 24 and 25
  24. limit 26 to yr=“2007 – 2009”

Database: Ovid MEDLINE® 1950 to week 4 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. monoclonal _ntibody$.mp.
  6. exp Antibodies, Monoclonal/
  7. synagis.mp.
  8. exp Immunotherapy/or immunoprophylaxis.mp.
  9. or/5-9
  10. 4 and 10
  11. randomized controlled trial.pt.
  12. controlled clinical trial.pt.
  13. randomized controlled trials.sh.
  14. random allocation.sh.
  15. double blind method.sh.
  16. single-blind method.sh.
  17. or/12-17
  18. (animals not human).sh.
  19. 18 not 19
  20. clinical trial.pt.
  21. (clin$adj25 trial$).ti,ab.
  22. ((singl$or doubl$or trebl$or tripl$) adj25 (blind$or mask$)).ti,ab.
  23. placebos.sh.
  24. placebo$.ti,ab.
  25. random$.ti,ab.
  26. research design.sh.
  27. or/21-27
  28. 28 not 19
  29. 29 not 20
  30. comparative study.sh.
  31. exp evaluation studies/
  32. follow up studies.sh.
  33. prospective studies.sh.
  34. (control$or _ntibody_ve$or volunteer$).ti,ab.
  35. or/31-35
  36. not 19
  37. 20 or 30 or 38
  38. 11 and 39
  39. limit 40 to yr=“2007 – 2009”

Database: EMBASE 1980 to week 31 2009

  1. exp Respiratory Syncytial Pneumovirus/or rsv.mp. or exp Bronchiolitis/
  2. bronchiolitis.mp.
  3. respiratory syncytial virus.mp.
  4. or/1-3
  5. palivizumab.mp. or exp PALIVIZUMAB/
  6. exp Monoclonal Antibody/or monoclonal _ntibody$.mp.
  7. synagis.mp.
  8. immunoprophylaxis.mp. or exp IMMUNOPROPHYLAXIS/
  9. or/5-8
  10. 4 and 9
  11. metaanalys$.ti,ab.
  12. meta-analys$.ti,ab.
  13. meta analys$.ti,ab.
  14. cochrane.ti,ab,de.
  15. (review$or overview$).ti,ab.
  16. (synthes$adj3 (literature$or research$or study or studies or data)).mp.
  17. pooled analy$.ti,ab.
  18. (systematic$adj2 review$).ti,ab.
  19. or/11-19
  20. 10 and 20
  21. 19 or 11
  22. 10 and 22
  23. limit 23 to yr=“2007 – 2009”

Database: EMBASE 1980 to week 31 2009

  1. exp Respiratory Syncytial Pneumovirus/or rsv.mp. or exp Bronchiolitis/
  2. bronchiolitis.mp.
  3. respiratory syncytial virus.mp.
  4. or/1-3
  5. palivizumab.mp. or exp PALIVIZUMAB/
  6. exp Monoclonal Antibody/or monoclonal _ntibody$.mp.
  7. synagis.mp.
  8. immunoprophylaxis.mp. or exp IMMUNOPROPHYLAXIS/
  9. or/5-8
  10. 4 and 9
  11. randomized controlled trial/
  12. exp clinical trial/
  13. exp controlled study/
  14. or/11-12
  15. 10 and 14
  16. limit 15 to yr=“2007 – 2009”

Database: CINAHL (EBSCO Host) 1982 to 4 August 2009

Terms used: RSV or respiratory syncytial virus or bronchiolitis or palivizumab or synagis or immunoprophylaxis or monoclonal _ntibody* random* or trial*

Database: Science Citation Index (Web of Science) 1900 to 4 August 2009

Terms used: RSV or respiratory syncytial virus or bronchiolitis or palivizumab or synagis or immunoprophylaxis or monoclonal _ntibody* or random* or trial*

Cost-effectiveness/modelling

Database: Ovid MEDLINE® 1950 to week 5 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. monoclonal _ntibody$.mp.
  6. exp Antibodies, Monoclonal/
  7. synagis.mp.
  8. exp Immunotherapy/or immunoprophylaxis.mp.
  9. or/5-9
  10. 4 and 10
  11. economics/
  12. exp “costs and cost analysis”/
  13. cost of illness/
  14. exp health care costs/
  15. economic value of life/
  16. exp economics medical/
  17. exp economics hospital/
  18. economics pharmaceutical/
  19. exp “fees and charges”/
  20. (econom$or cost or costs or costly or costing or price or pricing or pharmacoeconomic$).tw.
  21. (expenditure$not energy).tw.
  22. (value adj1 money).tw.
  23. budget$.tw.
  24. or/12-24
  25. 11 and 25
  26. limit 26 to yr=“2007 –Current”

Database: Ovid MEDLINE® 1950 to week 5 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. monoclonal _ntibody$.mp.)
  6. exp Antibodies, Monoclonal/
  7. synagis.mp.
  8. exp Immunotherapy/or immunoprophylaxis.mp.
  9. or/5-9
  10. 4 and 10
  11. decision support techniques/
  12. markov.mp.
  13. exp models economic/
  14. decision analysis.mp.
  15. cost benefit analysis/
  16. or/12-16
  17. 11 and 17
  18. 4 and 17
  19. 18 or 19
  20. limit 20 to yr=“2007 –Current”

Database: Ovid MEDLINE® 1950 to week 5 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. monoclonal _ntibody$.mp.
  6. exp Antibodies, Monoclonal/
  7. synagis.mp.
  8. exp Immunotherapy/or immunoprophylaxis.mp.
  9. or/5-9
  10. 4 and 10
  11. life style/
  12. health status/
  13. health status indicators/
  14. or/12-15
  15. 4 and 16
  16. limit 17 to yr=“2007 –Current”

Database: EMBASE 1980 to week 32 2009

  1. exp Respiratory Syncytial Pneumovirus/or rsv.mp. or exp Bronchiolitis/
  2. bronchiolitis.mp.
  3. respiratory syncytial virus.mp.
  4. or/1-3
  5. palivizumab.mp. or exp PALIVIZUMAB/
  6. exp Monoclonal Antibody/or monoclonal _ntibody$.mp.
  7. synagis.mp.
  8. immunoprophylaxis.mp. or exp IMMUNOPROPHYLAXIS/
  9. or/5-8
  10. 4 and 9
  11. cost benefit analysis/
  12. cost effectiveness analysis/
  13. cost minimization analysis/
  14. cost utility analysis/
  15. economic evaluation/
  16. (cost or costs or costed or costly or costing).tw.
  17. (economic$or pharmacoeconomic$or price$or pricing).tw.
  18. (technology adj assessment$).tw.
  19. or/11-18
  20. 10 and 19
  21. limit 20 to yr=“2007 –Current”

Database: EMBASE 1980 to week 32 2009

  1. exp Respiratory Syncytial Pneumovirus/or rsv.mp. or exp Bronchiolitis/
  2. bronchiolitis.mp.
  3. respiratory syncytial virus.mp.
  4. or/1-3
  5. quality of life.mp. or exp “Quality of Life”/
  6. health status.mp. or exp Health Status/
  7. or/5-6
  8. 4 and 7
  9. lung transplant$.mp.
  10. 8 not 9
  11. limit 10 to yr=“2007 –Current”

Database: EMBASE 1980 to week 32 2009

  1. exp Respiratory Syncytial Pneumovirus/or rsv.mp. or exp Bronchiolitis/
  2. bronchiolitis.mp.
  3. respiratory syncytial virus.mp.
  4. or/1-3
  5. palivizumab.mp. or exp PALIVIZUMAB/
  6. exp Monoclonal Antibody/or monoclonal _ntibody$.mp.
  7. synagis.mp.
  8. immunoprophylaxis.mp. or exp IMMUNOPROPHYLAXIS/
  9. or/5-8
  10. 4 and 9
  11. decision support technique$.mp.
  12. exp statistical model/or markov model$.mp.
  13. exp “cost effectiveness analysis”/or economic model$.mp.
  14. decision analysis.mp.
  15. or/11-14
  16. 10 and 15
  17. limit 16 to yr=“2007 –Current”

Additional searches

Prognosis

Database: Ovid MEDLINE® 1950 to week 4 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. prognosis.mp. or exp Prognosis/
  6. outcome$.mp.
  7. risk$.mp. or exp Risk Factors/
  8. hospitali?ation.mp.
  9. exp Follow-Up Studies/or follow-up.mp.
  10. complication$.mp.
  11. exp Cohort Studies/or cohort$.mp.
  12. or/5-10
  13. 4 and 12
  14. 11 and 13
  15. limit 14 to yr=“2007 – 2009”

Hospitalisation

Database: Ovid MEDLINE® 1950 to week 4 July 2009

  1. exp Respiratory Syncytial Virus, Human/or rsv.mp.
  2. respiratory syncytial virus.mp.
  3. bronchiolitis.mp. or exp Bronchiolitis, Viral/
  4. or/1-3
  5. hospitali?ation.mp.
  6. 4 and 5
  7. limit 6 to yr=“2007 – 2009”
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Bookshelf ID: NBK109543
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