Forest plot 13 is a metagraph comparing the specific adverse events between patients receiving haloperidol versus risperidone. Seven studies (n=619) found that akathisia occurred significantly less with risperidone (MD=1.78, 95 percent CI, 1.30, 2.43). Five studies contributed data from 1,596 patients and reported significantly fewer events of asthenia with risperidone (MD=1.19, 95 percent CI, 1.01, 1.40). Seven studies (n=1,870) reported on rates of constipation and no difference was found (MD=1.04, 95 percent CI, 0.61, 1.78); moderate statistical heterogeneity was present (p=0.16, I2=35%). Five studies (n=675) were pooled and found no difference in rates of EPS (MD=1.88, 95 percent CI, 1.49. 2.37). Nine studies (n=964) reported no significant difference for rates of headache (MD=0.83, 95 percent CI, 0.65, 1.06). Insomnia was reported in six studies (n=2,078) and found no difference (MD=1.08, 95 percent CI, 0.87, 1.34). Five studies (n=511) reported no difference on nausea/vomiting (MD=1.14, 95 percent CI, 0.72, 1.82). Five studies (n=549) reported somnolence and found no difference between groups (MD=1.09, 95 percent CI, 0.79, 1.49).

Forest plot 13Haloperidol versus risperidone–Specific adverse events

CI = confidence intervals; df = degrees of freedom; I2 = I–squared; IV = inverse variance; M-H = Mantel-Haenszel

From: Appendix J, Forest Plots for Adverse Events

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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