Table 27Characteristics of RCTs comparing haloperidol versus aripiprazole in the treatment of schizophrenia and other related psychoses

Study, Design (Followup)Interventions, Dosages; No. Randomized, Washout PeriodMain Inclusion CriteriaRisk of Bias,
Financial Support
Andrezina et al. 200644
RCT (24 hrs)
G1: HAL (6.5mg/2 hrs; max 3/d); (185)
G2: ARI (9.75mg/2 hrs; max 3/d); (175)
Sz or schizoaffective with agitation and no use of benzodiazepines or anticholinergics ≤4 hr; lack of response to previous APUnclear,
Industry
Daniel et al. 200774
RCT (5 d)
G1: HAL (6.5mg/d); (151)
G2: ARI (9.75mg/d); (153)
Acutely agitated Sz or schizoaffective disorderUnclear,
Industry
de Oliveira et al. 200976
RCT (8 wks)
G1: HAL (10–15mg/d); (33)
G2: ARI (15–30mg/d); (66)
Sz/schizoaffective disorderHigh,
Industry
Kane et al. 200292
RCT (4 wks)
G1: HAL (10mg/d); (104)
G2: ARI (15mg/d); (102)
G3: ARI (30mg/d); (102)
Washout period: <1 wks
Sz/schizoaffective disorder not refractory to antipsychotics; improvement with AP besides CLO; OP >1 3–month period <1 yrHigh,
Industry
Kasper et al. 200398
RCT (52 wks)
G1: HAL (5–10mg/d); (433)
G2: ARI (20–30mg/d); (861)
Washout period: ≥5 d
Acute relapse of Sz; response to AP (except CLO); no hx tx resistance; ≥3 mo OP AP use in last yr; PANSS total ≥60Unclear,
Industry
Kim et al. 2010102
RCT (8 wks)
G1: HAL (15.9±7.1mg/d); (35)
G2: ARI (21.7±5.5 mg/d); (31)
Washout period: >4wks
Sz not further definedUnclear,
Foundation
McCue et al. 200673
RCT (3 wks)
G1: HAL (4–30mg); (61)
G2: ARI (10–45mg); (63)
Sz, schizoaffective disorder or schizophreniform disorder; no hx of response or lack of response to AP, BP, major depression, or substance-induced psychotic disorderHigh,
No external funding
Tran-Johnson et al. 200731
RCT (24 hrs)
G1: HAL (7.5mg/d); (60)
G2: ARI (1mg/d); (57)
G3: ARI (5.25mg/d); (63)
G4: ARI (9.75mg/d); (57)
G5: ARI (15mg/d); (58)
Sz, schizoaffective, or schizophreniform disorder; acute agitationUnclear,
Industry

AP(s) = antipsychotic(s); ARI = aripiprazole; BP = bipolar disorder; CLO = clozapine; D = day; G = group; HAL = haloperidol; Hr(s) = hour(s); Hx = history; Max = maximum; Mg = milligram; OP = outpatient; PANSS = Positive and Negative Symptom Scale; RCT = randomized controlled trial; Sz = schizophrenia; Tx = treatment; Wk(s) = week(s); Yr(s) = year(s)

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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