Figure 23 is a metagraph depicting the effect of haloperidol versus risperidone on negative symptoms in patients with Sz. Twenty studies (n=4,043) were pooled to show a significant difference favoring risperidone (MD=0.60, 95 percent CI, 0.01, 1.20). Statistical heterogeneity was moderate (p=0.10, I2=30). Pooled results from four trials (n=506) showed a significant difference on the SANS scale favoring risperidone (MD=0.58, 95 percent CI, 0.37, 0.80).

Figure 23Haloperidol versus risperidone – Negative symptoms

CI = confidence intervals; df = degrees of freedom; I2 = I-squared; IV = inverse variance; PANSS = Positive and Negative Symptom Scale; SANS = Scale for the Assessment of Negative Symptoms; SD = standard deviation

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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