Figure 3 is a metagraph depicting the effect of chlorpromazine versus clozapine for total score on the BPRS for patients with Sz. Seven studies contributed data from 699 patients. Pooled results are displayed for patients with previous schizophrenic episodes and those with their first episode. For the six studies (n=535) comparing patients with previous episodes, the pooled estimates showed clozapine to be superior to chlorpromazine on BPRS scores (MD=8.40, 95 percent CI, 5.92, 10.88). For the one study (n=164) comparing treatment naïve patients, chlorpromazine was favored, although the difference was not significant (MD=−0.20, 95 percent CI, −1.38, 0.98).

Figure 3Chlorpromazine versus clozapine – core symptoms (Sz) – Total score

BPRS = Brief Psychiatric Rating Scale; CI = confidence intervals; df = degrees of freedom; I2 = I-squared; IV = inverse variance; SD = standard deviation; Sz = schizophrenia

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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