Table 9Risk of bias–haloperidol versus asenapine

StudyItemJudgmentDescription
Kane et al. 201097Adequate sequence generation?UNCLEARReported as a randomized trial, with no further details.
Allocation concealment?UNCLEARAllocation concealment was not reported.
Blinding?UNCLEARReported as a DB, placebo-controlled trial, with no further details regarding the methods used for blinding.
Incomplete outcome data addressed?YESITT analysis was not used, but 98% of randomized participants were included in the analyses.
Free of selective reporting?UNCLEARInterSePT and RDQ are reported as trial outcomes, but no extractable data is reported (i.e., only reported that changes from baseline to endpoint were small).
Free of other bias?YESNo significant differences in baseline characteristics or other sources of bias detected.

DB = double-blind; ITT = intention-to-treat analysis; RDQ = Readiness to Discharge Questionnaire

From: Appendix E, Risk of Bias Assessment for Randomized Controlled Trials and Nonrandomized Controlled Trials

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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