Table 3Risk of bias–chlorpromazine versus quetiapine

StudyItemJudgmentDescription
Peuskens et al. 1997121Adequate sequence generation?UNCLEARReported as a randomized trial, with no further details.
Allocation concealment?UNCLEARNo information reported regarding allocation concealment in the trial report.
Blinding?UNCLEARReported as a DB trial, with no further details regarding the methods used for blinding.
Incomplete outcome data addressed?YESITT performed on 196/201 (98%) of randomized patients.
Free of selective reporting?YESProtocol was not available, but outcomes in the methods and results are similar.
Free of other bias?YESNo significant differences in baseline characteristics or other sources of bias detected.

DB = double-blind; ITT = intention-to-treat analysis

From: Appendix E, Risk of Bias Assessment for Randomized Controlled Trials and Nonrandomized Controlled Trials

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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