Table 99Subgroup and sensitivity analyses: haloperidol vs. olanzapine – Total scores (PANSS Scale)

Total SymptomsStudiesParticipantsEffect EstimateI2Favors
OVERALL POOLED RESULTS1542092.31 (0.44, 4.18)37%olanzapine
Disorder subtypes
Paranoid schizophrenia128−0.65 (−4.77, 3.47)NEND
Schizoaffective disorder35932.13 (−0.91, 5.17)0%ND
Mixed1135882.65 (0.17, 5.12)42%olanzapine
Co-morbid drug/alcohol use
Excluded3483−0.73 (−5.83, 4.38)0%ND
Mixed1237262.71 (0.75, 4.67)40%olanzapine
Treatment resistance
Treatment resistant622312.54 (−2.21, 7.29)56%ND
Mixed817702.25 (0.00, 4.50)23%ND
No treatment resistance12080.90 (−3.81, 5.61)NEND
Duration of followup
≤6 weeks251−4.88 (−17.94, 8.18)0%ND
>6 weeks and <6 months76952.26 (−1.85, 6.37)61%ND
≥6 months634633.47 (1.99, 4.94)0%olanzapine
Dosage of FGA (haloperidol)
≤20mg/d1340602.74 (1.02, 4.46)23%olanzapine
>20mg/d21490.79 (−10.00, 11.58)77%ND
Dosage of SGA (olanzapine)
≤20mg/d1340602.74 (1.02, 4.46)23%olanzapine
Upper limit >20mg/d21490.79 (−10.00, 11.58)77%ND
Source of funding
Industry funding1340032.21 (0.15, 4.26)45%olanzapine
No industry funding reported22063.34 (−2.21, 8.90)0%ND
Risk of bias
Unclear1320052.01 (−0.30, 4.33)35%ND
High222043.30 (0.27, 6.34)41%olanzapine
Race
Other1439332.01 (0.13, 3.89)36%olanzapine
Asian12767.90 (0.96, 14.84)NEolanzapine
Data analysis
Imputed data3364−1.50 (−4.54, 1.54)0%ND
No imputed data1238453.68 (2.17, 5.18)5%olanzapine

Significant results are in bold. d = day; FGA = first generation antipsychotic; I2 = I–squared; mg = milligrams; ND = no difference; NE = not estimable; PANSS = Positive and Negative Syndrome Scale; SGA = second generation antipsychotic

From: Appendix M, Subgroup and Sensitivity Analyses

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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