Table 97Subgroup and sensitivity analyses: haloperidol vs. olanzapine – Negative symptoms (PANSS Scale)

Total SymptomsStudiesParticipantsEffect EstimateI2Favors
OVERALL POOLED RESULTS1437421.06 (0.46, 1.67)27%olanzapine
Disorder subtypes
Schizoaffective disorder specifically included1762.50 (−0.18, 5.18)NEND
Mixed1336660.99 (0.37, 1.62)29%olanzapine
Co-morbid drug/alcohol use
Excluded45270.88 (−0.63, 2.39)0%ND
Included only131−3.20 (−6.03, −0.37)NEhaloperidol
Mixed931841.27 (0.82, 1.72)2%olanzapine
Treatment resistance
Treatment resistant522071.28 (0.11, 2.44)40%olanzapine
Mixed814910.90 (−0.02, 1.81)35%ND
No treatment resistance1441.02 (−2.39, 4.43)NEND
Duration of followup
≤6 weeks258−1.87 (−5.12, 1.39)42%ND
>6 weeks and <6 months76941.37 (0.25, 2.50)25%olanzapine
≥6 months529901.26 (0.79, 1.73)0%olanzapine
Dosage of FGA (haloperidol)
≤20mg/d1235931.13 (0.51, 1.75)24%olanzapine
Upper limit >20mg/d21490.92 (−1.78, 3.62)65%ND
Dosage of SGA (olanzapine)
≤20mg/d1235931.13 (0.51, 1.75)24%olanzapine
>20mg/d21490.92 (−1.78, 3.62)65%ND
Source of funding
Industry funding1335601.08 (0.40, 1.76)32%olanzapine
No industry funding reported11820.82 (−0.69, 2.33)NEND
Risk of bias
Unclear1116881.18 (0.58, 1.78)0%olanzapine
High32054−0.33 (−3.82, 3.16)79%ND
Other1334660.97 (0.34, 1.59)27%olanzapine
Asian12762.40 (0.35, 4.45)NEolanzapine
Data analysis
Imputed data23360.69 (−1.04, 2.41)56%ND
No imputed data1234061.14 (0.45, 1.83)28%olanzapine

Significant results are in bold. d = day; FGA = first generation antipsychotic; I2 = I–squared; mg = milligrams; ND = no difference; NE = not estimable; PANSS = Positive and Negative Syndrome Scale; SGA = second generation antipsychotic

From: Appendix M, Subgroup and Sensitivity Analyses

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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