Table 66Patient flow through trials–haloperidol versus olanzapine

Intervention #1Intervention #2Intervention #3Intervention #4Intervention #5Intervention #6
Altamura et al. 200243ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage10–20mg/d10–20mg/d
No screened:NR
No randomized:1513
No completed:813
No analyzed (E):1113
No analyzed (S):1113
Alvarez–Jimenez et al. 2006142ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage3–9mg/d5–20mg/d3–6mg/d
No screened:NR
No randomized:201724
No completed:201724
No analyzed (E):201724
No analyzed (S):201724
Beasley et al. 199649ClassificationFGASGASGASGA
MedicationHaloperidolOlanzapineOlanzapineOlanzapine
Dosage10–20mg/d2.5–7.5mg/d7.5–12.5mg/d12.5–17.5mg/d
No screened:335
No randomized:69656469
No completed:30303034
No analyzed (E):18161927
No analyzed (S):69656469
Beasley et al. 199750ClassificationFGASGASGASGASGA
MedicationHaloperidolOlanzapineOlanzapineOlanzapineOlanzapine
Dosage15±5mg/d1.0mg/d5±2.5mg/d10±2.5mg/d15±2.5mg/d
No screened:NR
No randomized:8188878689
No completed:4348485355
No analyzed (E):7983858385
No analyzed (S):8188878689
Bernardo et al. 200151ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage10mg/d10mg/d
No screened:NR
No randomized:1314
No completed:NRNR
No analyzed (E):1314
No analyzed (S):1314
Boulay et al. 200754ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage2.5–20mg/d2.5–20mg/d
No screened:NR
No randomized:1314
No completed:814
No analyzed (E):1114
No analyzed (S):1114
Breier et al. 200256ClassificationFGASGASGASGASGA
MedicationHaloperidolOlanzapineOlanzapineOlanzapineOlanzapine
Dosage7.5mg2.5mg5.0mg7.5mg10.0mg
No screened:NR
No randomized:4048454646
No completed:4048434646
No analyzed (E):4048434646
No analyzed (S):4048434646
Buchanan et al. 200558ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage10–30mg/d10–30mg/d
No screened:68
No randomized:3429
No completed:3126
No analyzed (E):3429
No analyzed (S):3429
Citrome et al. 200162ClassificationFGASGASGASGA
MedicationHaloperidolClozapineOlanzapineRisperidone
Dosage10–30mg/d200–800mg/d10–40mg/d4–16mg/d
No screened:NR
No randomized:37403941
No completed:27323028
No analyzed (E):37403941
No analyzed (S):37403941
Crespo–Facorro et al. 200671ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage3–9mg/d5–20mg/d3–6mg/d
No screened:202
No randomized:565561
No completed:555357
No analyzed (E):565561
No analyzed (S):565561
Davidson et al. 200975ClassificationFGASGASGASGA
MedicationHaloperidolOlanzapineQuetiapineZiprasidone
Dosage1–4mg/d5–20mg/d200–750mg/d40–160mg/d
No screened:NR
No randomized:10310410582
No completed:52607445
No analyzed (E):52607445
No analyzed (S):52607445
de Haan et al. 200378ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage2.5mg/d7.5mg/d
No screened:NR
No randomized:1212
No completed:109
No analyzed (E):109
No analyzed (S):109
Goldman et al. 200484ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg/d5–20mg/d
No screened:NR
No randomized:55
No completed:25
No analyzed (E):55
No analyzed (S):55
Ishigooka et al. 200188ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage4–12mg/d5–15mg/d
No screened:NR
No randomized:8993
No completed:5975
No analyzed (E):7880
No analyzed (S):8490
Kahn et al. 200891ClassificationFGASGASGASGA
MedicationHaloperidolOlanzapineQuetiapineZiprasidone
Dosage1–4mg/d5–20mg/d200–750mg/d40–16mg/d
No screened:1047
No randomized:10310510482
No completed:68827053
No analyzed (E):10310510482
No analyzed (S):10310510482
Keefe et al. 2006101ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage2–19mg/d5–20mg/d2–10mg/d
No screened:414
No randomized:97159158
No completed:276454
No analyzed (E):94153148
No analyzed (S):97159158
Kim et al. 2010102ClassificationFGASGASGASGA
MedicationHaloperidolAripiprazoleOlanzapineRisperidone
Dosage15.9+/−7.1mg/d21.7+/−5.5mg/d15.9+/−4.3mg/d4.8+/−2.9mg/d
No screened:NR
No randomized:35313241
No completed:NRNRNRNR
No analyzed (E):NRNRNRNR
No analyzed (S):NRNRNRNR
Kongsakon et al. 2006104ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg5–20mg
No screened:440
No randomized:132144
No completed:94113
No analyzed (E):123139
No analyzed (S):124139
Krakowski et al. 2006105ClassificationFGASGASGA
MedicationHaloperidolClozapineOlanzapine
Dosage10–30mg/d200–800mg/d10–35mg/d
No screened:134
No randomized:363737
No completed:202426
No analyzed (E):363737
No analyzed (S):363737
Lahti et al. 2009106ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage10–20mg/d12.5–25mg/d
No screened:37
No randomized:1418
No completed:1217
No analyzed (E):1217
No analyzed (S):1217
Lieberman et al. 2003108ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage2–20mg/d5–20mg/d
No screened:263
No randomized:132131
No completed:7189
No analyzed (E):132131
No analyzed (S):132131
Lindenmayer et al. 2007110ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg/d5–20mg/d
No screened:36
No randomized:1916
No completed:1916
No analyzed (E):1615
No analyzed (S):1615
McCue et al. 200673ClassificationFGASGASGASGASGASGA
MedicationHaloperidolAripiprazoleOlanzapineQuetiapineRisperidoneZiprasidone
Dosage4–30mg10–45mg5–40mg50–1200mg2–9mg40–240mg
No screened:584
No randomized:616362586559
No completed:534950505545
No analyzed (E):575350525750
No analyzed (S):575350525750
Purdon et al. 2000124ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage5–20mg/d5–20mg/d2–6mg/d
No screened:NR
No randomized:232121
No completed:9127
No analyzed (E):232121
No analyzed (S):232121
Rosenheck et al. 2003127ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg/d5–20mg/d
No screened:4386
No randomized:150159
No completed:6468
No analyzed (E):150159
No analyzed (S):150159
Saddichha et al. 2008129ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage13.4+/−3.6mg/d16.5+/−4.6mg/d4.4+/−1.2mg/d
No screened:NR
No randomized:NRNRNR
No completed:313533
No analyzed (E):313533
No analyzed (S):NRNR
Sayers et al. 2005130ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage10–20 mg/d10–20mg/d
No screened:170
No randomized:1212
No completed:77
No analyzed (E):1212
No analyzed (S):1212
Sergi et al. 2007134ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage8mg/d15mg/d4mg/d
No screened:NR
No randomized:204040
No completed:122225
No analyzed (E):132832
No analyzed (S):132832
Smelson et al. 2006136ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg/d5–20mg/d
No screened:NR
No randomized:1516
No completed:108
No analyzed (E):1516
No analyzed (S):NRNR
Smith et al. 2001137ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–40mg/d5–20mg/d
No screened:NR
No randomized:NRNR
No completed:1316
No analyzed (E):1316
No analyzed (S):NRNR
Tollefson et al. 1997141ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage5–20mg/d5–20mg/d
No screened:2223
No randomized:6601336
No completed:309888
No analyzed (E):6601336
No analyzed (S):6601336
Volakva et al. 2002145ClassificationFGASGASGASGA
MedicationHaloperidolClozapineOlanzapineRisperidone
Dosage10–30mg/d200–800mg/d10–40mg/d4–16mg/d
No screened:NR
No randomized:37403941
No completed:21222622
No analyzed (E):37403941
No analyzed (S):37403941
Wright et al. 2001147ClassificationFGASGA
MedicationHaloperidolOlanzapine
Dosage7.5mg10mg
No screened:311
No randomized:126131
No completed:126131
No analyzed (E):126131
No analyzed (S):126131
Wynn et al. 2007148ClassificationFGASGASGA
MedicationHaloperidolOlanzapineRisperidone
Dosage8mg/d15mg/d4mg/d
No screened:100
No randomized:112119
No completed:71614
No analyzed (E):112119
No analyzed (S):71614

d = day; E = efficacy; FGA = first-generation antipsychotic; mg = milligram; No = number; NR = not reported; S = safety; SGA = second-generation antipsychotic

From: Appendix I, Patient Flow Through Trials

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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