FIGURE 5.5. CB1 receptor levels were found to be lower in the membranes isolated from ventral striatum of chronic alcoholics (CA, 74%, ***p < 0.

FIGURE 5.5

CB1 receptor levels were found to be lower in the membranes isolated from ventral striatum of chronic alcoholics (CA, 74%, ***p < 0.0001; (A)) and alcoholic suicide victims (AS, 48%, **p < 0.001; (A)) compared to normal controls (n = 9 in each group). However, a marked higher level of CB1 receptors was evident in the CA (98%, *p < 0.05; (A)) compared to CA subjects. A representative immunoblot of CB1 receptor is shown in the upper panel. The CB1 receptor–mediated G-protein activation was also significantly lower in ventral striatum of CA (35%, *p < 0.01; (B)) compared to normal controls; it was found to be higher in AS (32%, **p < 0.001; (B)) compared to the CA group. (Adapted from Vinod, K.Y. et al., J. Psychiatr. Res., 44, 591, 2010.)

From: Chapter 5, Role of the Endocannabinoid System in the Neurobiology of Suicide

Cover of The Neurobiological Basis of Suicide
The Neurobiological Basis of Suicide.
Dwivedi Y, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2012.
Copyright © 2012 by Taylor & Francis Group, LLC.

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