Table 3

Efficacy outcomes in acute treatment of bipolar disorder with carbamazepine compared with lithium

Study NCarbamazepine doseLithium doseEfficacy outcomes
Lerer 1987 N=341400 mg/d (8.8 μg/mL)2100 mg (0.87 μg/mL)% improvement in mean CGI score: 26.8% compared with 45.6%; P=NS
Okuma 1990 N=101614 mg/d (7.5 μg/mL)635 mg (0.39 μg/mL)Marked/moderate improvements on CGI (% patients): 62% compared with 59%; P=NS
Small 1991 N=521036 mg/d (37 μmol/L)1155 mg (0.73 mmol/L)% improvement in mean YMRS score: 28% compared with 32%; P=NS

From: Results

Cover of Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy
Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet].
McDonagh M, Peterson K, Lee N, et al.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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