Table 11

Risk of adverse events with antiepileptic drugs compared with placebo

DrugRelative risk of any adverse event (95% CI)aRelative risk of withdrawal due to adverse events (95% CI)a
Carbamazepine1.63 (1.14 to 2.33) ER 1.40 (1.04 to 1.88)ER 1.98 (1.02 to 3.86)
Gabapentin1.38 (0.97 to 1.95)1.63 (0.93 to 2.84)
Lamotrigine1.03 (0.93 to 1.13)1.30 (0.96 to 1.77)
PhenytoinNR23.12 (0.26 to 2033)
Pregabalin1.23 (0.98 to 1.53)1.81 (0.95 to 3.43)
Topiramate1.15 (1.04 to 1.27)2.22 (1.76 to 2.80)
Valproate1.14 (0.96 to 1.35)2.23 (1.47 to 3.40)
IR 1.33 (0.90 to 1.97)IR 2.95 (1.66 to 5.26)
ER 1.07 (0.89 to 1.29)ER 1.68 (0.53 to 5.33)

Abbreviations: ER, extended release; IR, immediate release.

a

DerSimmonian and Laird random-effects model.

DerSimmonian and Laird random-effects model.

From: Results

Cover of Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy
Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet].
McDonagh M, Peterson K, Lee N, et al.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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