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Cover of Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy

Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy

Final Report Update 2

Drug Class Reviews

, PharmD, , MS, , PharmD, and , MPA:HA.

Oregon Evidence-based Practice Center, Oregon Health & Science University, Mark Helfand, MD, MPH, Director
Portland (OR): Oregon Health & Science University; .

Antiepileptic drugs have been used beyond treatment of seizure disorders since the 1960s. As new antiepileptic drugs have become available, there has been interest in how they compare with older therapies (carbamazepine, phenytoin, and valproate) and each other in disorders where conventional pharmacotherapy has typically been suboptimal and limited by drug-related toxicity. The objective of this report is to evaluate the comparative effectiveness and harms of antiepileptic drugs used for bipolar disorder, fibromyalgia, migraine prophylaxis, and chronic pain.

Original report and Update 1: Southern California Evidence-based Practice Center, RAND, Paul Shekelle, MD, PhD, Director.

Leah Williams and Arkady Mak, PhD, MD, contributed to this report by formatting and editing the manuscript. Laurie Huffman, MS, Brittany Burda, BS, Trish Thieda, MA, Miranda Walker, MA, and Tracy Dana, MLS assisted with data abstraction and quality assessment of studies. Theresa Nguyen and Allison Low assisted through article retrieval, and assistance with editing and formatting.

The Drug Effectiveness Review Project, made up of 15 organizations including 14 state Medicaid agencies, commissioned and funded this report. These organizations selected the topic of the report and had input into its Key Questions. Content and conclusions of the report were determined entirely by researchers at the Evidence-based Practice Center. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in the report.

Suggested citation:

McDonagh M, Peterson K, Lee N, Thakurta S. Drug class review: Antiepileptic drugs for indications other than epilepsy. Update 2.

The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports.

Copyright © 2008, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK10371PMID: 20480927
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