Table 8Characteristics of studies addressing KQ5

Author Year
[PMID]
Index TestFundingStudy DesignEnrollment PeriodFollowup DurationDiagnostic CriteriaQuality Grade and Issues
Chee 2009,47
[19641191]
SFLC ratioGovernmentRetrospective cohortnd1995–??MM, measurable M protein concentrations at baseline (serum M protein ≤1 g/dL or urine M protein ≤0.2 g/day), and since start of study, negative SIFE and UIFE with concomitant bone marrow aspirate or biopsy and normal SFLC ratio (with all tests performed within 30 days of each other)C (retrospective, small convenience sample)

KQ=Key Question, MM=multiple myeloma, nd=no data, SFLC=serum free light chain, SIFE=serum immunofixation electrophoresis, UIFE=urine immunofixation electrophoresis.

From: Results

Cover of Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias
Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias [Internet].
Comparative Effectiveness Reviews, No. 73.
Rao M, Yu WW, Chan J, et al.

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