Figure 12.33. Growth factors and epidermal proliferation.

Figure 12.33

Growth factors and epidermal proliferation. (A) A wild-type mouse pup. (B) A littermate of (A) that is expressing high levels of TGF-α in its keratinocytes. It has scaly skin and very little hair. Below each mouse is a cross section through its skin. The mouse overexpressing TGF-α has very extensive layers of keratinized epithelia, which it sheds. (C) A transgenic mouse expressing low levels of KGF in its keratinocytes. Note the sparsity of hair around the legs, eyes, and nose. The skin section shows an absence of hair follicles and an increased number of basal epidermal cells. Beneath each mouse is a section of its skin. (From Vassar and Fuchs 1991; Guo et al. 1993; photographs courtesy of E. Fuchs.)

From: The Epidermis and the Origin of Cutaneous Structures

Cover of Developmental Biology
Developmental Biology. 6th edition.
Gilbert SF.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Sinauer Associates.

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