PubMed for Bookshelf ID: 3087532

Year	Number of Results
1990	1
1991	1
1993	1
1997	1
2006	1
2008	2
2010	1
2011	1
2012	4
2013	1
2024	0

1

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Tari LW, Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Nix J, Finn J. Tari LW, et al. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1529-36. doi: 10.1016/j.bmcl.2012.11.032. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23352267

2

Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor.

Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach MA, DeRisi JL, Iwatsuki M, Ōmura S, Khosla C. Holmes TC, et al. J Am Chem Soc. 2012 Oct 24;134(42):17797-806. doi: 10.1021/ja308622d. Epub 2012 Oct 10. J Am Chem Soc. 2012. PMID: 23030602 Free PMC article.

3

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.

Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE, Khosla C. Kapur S, et al. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4110-5. doi: 10.1073/pnas.1118734109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371562 Free PMC article.

4

Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery.

Manchester JI, Buurman ET, Bisacchi GS, McLaughlin RE. Manchester JI, et al. J Med Chem. 2012 Mar 22;55(6):2532-7. doi: 10.1021/jm201275d. Epub 2012 Jan 27. J Med Chem. 2012. PMID: 22224562 No abstract available.

5

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.

Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RG, Singh SB. Phillips JW, et al. Chem Biol. 2011 Aug 26;18(8):955-65. doi: 10.1016/j.chembiol.2011.06.011. Chem Biol. 2011. PMID: 21867911

6

Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus.

Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME. Haste NM, et al. J Antibiot (Tokyo). 2010 May;63(5):219-24. doi: 10.1038/ja.2010.22. Epub 2010 Mar 26. J Antibiot (Tokyo). 2010. PMID: 20339399 Free PMC article.

7

Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II: physico-chemical properties and structure elucidation.

Iwatsuki M, Uchida R, Yoshijima H, Ui H, Shiomi K, Kim YP, Hirose T, Sunazuka T, Abe A, Tomoda H, Omura S. Iwatsuki M, et al. J Antibiot (Tokyo). 2008 Apr;61(4):230-6. doi: 10.1038/ja.2008.33. J Antibiot (Tokyo). 2008. PMID: 18503202

8

Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties.

Iwatsuki M, Uchida R, Yoshijima H, Ui H, Shiomi K, Matsumoto A, Takahashi Y, Abe A, Tomoda H, Omura S. Iwatsuki M, et al. J Antibiot (Tokyo). 2008 Apr;61(4):222-9. doi: 10.1038/ja.2008.32. J Antibiot (Tokyo). 2008. PMID: 18503201

9

Discovery of FabH/FabF inhibitors from natural products.

Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J. Young K, et al. Antimicrob Agents Chemother. 2006 Feb;50(2):519-26. doi: 10.1128/AAC.50.2.519-526.2006. Antimicrob Agents Chemother. 2006. PMID: 16436705 Free PMC article.

10

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. Jacobsen JR, et al. Science. 1997 Jul 18;277(5324):367-9. doi: 10.1126/science.277.5324.367. Science. 1997. PMID: 9219693

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