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Results: 1 to 20 of 246

1.

Separation of Sister Chromatids

While sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/cyclosome (APC/C) ubiquitinates PTTG1 (securin), targeting it for degradation (Hagting...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269826
REACTOME
: R-HSA-2467813
2.

Resolution of Sister Chromatid Cohesion

The resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. 2001, Hauf et al. 2005). CDK1-mediated phosphorylation of cohesin-bound CDCA5 (Sororin)...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269821
REACTOME
: R-HSA-2500257
3.

RHO GTPases Activate Formins

Formins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are activated by RHO GTPases. Formins that serve as effectors of RHO GTPases belong to different...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269519
REACTOME
: R-HSA-5663220
4.

Kinesins

Kinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 families of kinesins, all reprsented in humans. A standardized nomenclature was published...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269378
REACTOME
: R-HSA-983189
5.

MHC class II antigen presentation

Antigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exogenous antigenic peptides to CD4+ T helper cells. CD4+ T cells play a central role...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269200
REACTOME
: R-HSA-2132295
6.

RHO GTPase Effectors

RHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall 2002).One of the best studied RHO GTPase effectors are protein kinases ROCK1 and...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269509
REACTOME
: R-HSA-195258
7.

Signaling by Rho GTPases

The Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as binary switches controlling a variety of biological processes. They perform this function...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269507
REACTOME
: R-HSA-194315
8.

Factors involved in megakaryocyte development and platelet production

Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269377
REACTOME
: R-HSA-983231
9.

Hemostasis

Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269340
REACTOME
: R-HSA-109582
10.

Adaptive Immune System

Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269171
REACTOME
: R-HSA-1280218
11.

Mitotic Anaphase

In anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement along the spindle microtubules and through the physical interaction of polar microt...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269825
REACTOME
: R-HSA-68882
12.

Mitotic Metaphase and Anaphase

Metaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ensure that later, when the chromosomes are separated, each new nucleus that is formed...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269823
REACTOME
: R-HSA-2555396
13.

Mitotic Prometaphase

The dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and the chromosomes begin to move to the metaphase plate.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269820
REACTOME
: R-HSA-68877
14.

Signal Transduction

Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1269379
REACTOME
: R-HSA-162582
15.

mitotic cell cycle process

A process that is part of the mitotic cell cycle.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
987848
GO
: GO:1903047
16.

microtubule cytoskeleton organization involved in mitosis

Any microtubule cytoskeleton organization that is involved in mitosis. Synonyms: microtubule cytoskeleton organisation involved in mitosis; microtubule cytoskeleton organization and biogenesis involved in mitosis; microtubule dynamics involved in mitosis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
982420
GO
: GO:1902850
17.

regulation of mitotic cell cycle phase transition

Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition. Synonym: mitotic cell cycle control;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
781979
GO
: GO:1901990
18.

regulation of cell cycle phase transition

Any process that modulates the frequency, rate or extent of cell cycle phase transition. Synonyms: cell cycle control; regulation of cell cycle transition;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
781976
GO
: GO:1901987
19.

mitotic spindle midzone

The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
754890
GO
: GO:1990023
20.

carbohydrate derivative binding

Interacting selectively and non-covalently with a carbohydrate derivative.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
752867
GO
: GO:0097367

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