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Results: 1 to 20 of 91

1.

African trypanosomiasis

Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

L-kynurenine degradation

General Background : TRP "Tryptophan" is an essential amino acid in mammals, that must be obtained in the diet. It is utilized for protein synthesis. In most tissues, : TRP is catabolized via the kynurenine pathway. This is the major catabolic route of : TRP and an anabolic source...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
907939
BIOCYC
: HUMAN_PWY-6309
3.

tryptophan degradation

General Background The major catabolic route of : TRP metabolism in mammals also leads to the formation of NAD, see : NADSYN-PWY. This complex network of biochemical transformations generates a number of neurologically active compounds, including : QUINOLINATE and : KYNURENATE, some...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
142385
BIOCYC
: HUMAN_TRYPTOPHAN-DEGRADATION-1
4.

NAD de novo biosynthesis

General Background Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative, nicotinamide adenine dinucleotidephosphate (NADP) are two of the most important coenzymes in redox reactions in the cell. Generally, NAD is involved in catabolic reactions, while NADP is...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
142215
BIOCYC
: HUMAN_NADSYN-PWY
5.

Tryptophan catabolism

Tryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Tryptophan metabolism

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

African trypanosomiasis

Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
8.

tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

This upstream portion of tryptophan degradation is found in many eukaryotes (including all metazoa) and some prokaryotes. The compound : 2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI, at which this pathway ends, is a branching point: it can be processed via : 2K-ADIPATE to be completely...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
142383
BIOCYC
: HUMAN_PWY-5651
9.

Metabolic pathways

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Metabolism of amino acids and derivatives

This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

superpathway of tryptophan utilization

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
835392
BIOCYC
: HUMAN_PWY66-401
12.

organic cyclic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. Synonyms: organic cyclic compound breakdown; organic cyclic compound catabolism; organic cyclic compound degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754323
GO
: GO:1901361
13.

organic cyclic compound binding

Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
752660
GO
: GO:0097159
14.

kynurenine metabolic process

The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. Synonym: kynurenine metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
515126
GO
: GO:0070189
15.

dioxygenase activity

Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
512109
GO
: GO:0051213
16.

tetrapyrrole binding

Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. Synonym: porphyrin binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
509113
GO
: GO:0046906
17.

heterocycle metabolic process

The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). Synonym: heterocycle metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
508743
GO
: GO:0046483
18.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. Synonyms: carboxylic acid breakdown; carboxylic acid catabolism; carboxylic acid degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
508658
GO
: GO:0046395
19.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. Synonym: small molecule metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507288
GO
: GO:0044281
20.

cellular nitrogen compound catabolic process

The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. Synonyms: nitrogen compound breakdown; nitrogen compound catabolism; nitrogen compound degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507277
GO
: GO:0044270

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