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Results: 1 to 20 of 221

1.

HDR through Single Strand Annealing (SSA)

Homology directed repair (HDR) through single strand annealing (SSA), similar to HDR through homologous recombination repair (HRR), involves extensive resection of DNA double strand break ends (DSBs), preceded by ATM activation and formation of the so-called ionizing radiation induced...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

In the synthesis-dependent strand-annealing (SDSA) model of D-loop resolution, D-loop strands extended by DNA repair synthesis dissociate from their sister chromatid complements and reanneal with their original complementary strands, resulting in non-crossover products (Mitchel et...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Resolution of D-loop Structures through Holliday Junction Intermediates

D-loops generated after strand invasion and DNA repair synthesis during homologous recombination repair (HRR) can be resolved through Holliday junction intermediates.A D-loop can be cleaved by the complex of MUS81 and EME1 (MUS81:EME1) or MUS81 and EME2 (MUS81:EME2) and resolved without...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Resolution of D-Loop Structures

Once repair synthesis has occurred, the D-loop structure may be resolved either through Holliday junction intermediates or through synthesis-dependent strand-annealing (SDSA) (Prado and Aguilera 2003, Ciccia and Elledge 2010).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Presynaptic phase of homologous DNA pairing and strand exchange

The presynaptic phase of homologous DNA pairing and strand exchange during homologous recombination repair (HRR) begins with the displacement of RPA from ssDNA (Thompson and Limoli 2003) by the joint action of RAD51 and BRCA2. CHEK1-mediated phosphorylation of RAD51 and BRCA2 (Sorensen...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Homologous DNA Pairing and Strand Exchange

The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from 3'-ssDNA overhangs created by extensive resection of DNA double strand break (DSB) ends. RPA is displaced by the joint action of RAD51 and BRCA2. BRCA2 nucleates RAD51 on 3'-ssDNA...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

HDR through Homologous Recombination (HRR)

Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Processing of DNA double-strand break ends

Homology directed repair (HDR) through homologous recombination (HRR) or single strand annealing (SSA) requires extensive resection of DNA double strand break (DSB) ends (Thompson and Limoli 2003, Ciccia and Elledge 2010). The resection is performed in a two-step process, where the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)

Homology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM followed by ATM-mediated phosphorylation of DNA repair proteins. ATM coordinates the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Homology Directed Repair

Homology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homologous sequence can then be used as a template for DNA repair synthesis that bridges...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

DNA Double-Strand Break Repair

Numerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-strand breaks (DSBs), one of the most dangerous type of DNA damage along with interstrand...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
12.

DNA Repair

DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, environmental chemicals and radiation that damage their DNA, thus corrupting genetic information....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
13.

Cytosolic iron-sulfur cluster assembly

Iron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in Lill et al. 2012, Rouault et al. 2012, Sharma et al. 2010, Lill and Muhlenhoff 2006)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
14.

Metabolism

Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
15.

regulation of nucleic acid-templated transcription

Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129333
GO
: GO:1903506
16.

negative regulation of cell cycle phase transition

Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. Synonyms: down regulation of cell cycle phase transition; down regulation of cell cycle transition; down-regulation of cell cycle phase transition; down-regulation of cell cycle...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
781977
GO
: GO:1901988
17.

regulation of cell cycle phase transition

Any process that modulates the frequency, rate or extent of cell cycle phase transition. Synonyms: cell cycle control; regulation of cell cycle transition;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
781976
GO
: GO:1901987
18.

regulation of RNA biosynthetic process

Any process that modulates the frequency, rate or extent of RNA biosynthetic process. Synonyms: regulation of RNA anabolism; regulation of RNA biosynthesis; regulation of RNA formation; regulation of RNA synthesis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
755247
GO
: GO:2001141
19.

glycosyl compound catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosyl compound. Synonyms: glycosyl compound breakdown; glycosyl compound catabolism; glycosyl compound degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754610
GO
: GO:1901658
20.

glycosyl compound metabolic process

The chemical reactions and pathways involving glycosyl compound. Synonym: glycosyl compound metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754609
GO
: GO:1901657

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