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biosynthesis of prostaglandins

Prostaglandins are potent lipid mediators derived from arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. Prostaglandins are formed by most cells in our bodies and act as autocrine and paracrine lipid mediators. They are not stored but are synthesized de novo from membrane-released arachidonic acid when cells are activated by mechanical trauma or by specific cytokine, growth factor, and other stimuli . At physiologic pH, prostaglandins traverse biologic membranes poorly. Accordingly, PG transport is carrier-mediated in many tissues. The prostaglandin transporter, Slco2a1, was first cloned in rats . Subsequently, the human and mouse prostaglandin transporters were cloned.

from BIOCYC source record: MOUSE_PWY3DJ-35583
Type: pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
BSID:
142890

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