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Results: 13

1.

TIR domain binding

Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions,...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
515903
GO
: GO:0070976
2.

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. Synonyms: NF-kappaB activation; activation of NF-kappaB; activation of NF-kappaB transcription factor;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512006
GO
: GO:0051092
3.

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
509171
GO
: GO:0046982
4.

regulation of innate immune response

Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507488
GO
: GO:0045088
5.

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. Synonyms: activation of I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; stimulation of I-kappaB kinase/NF-kappaB cascade; up regulation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
506197
GO
: GO:0043123
6.

Toll-like receptor 2 binding

Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. Synonym: TLR2 binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
504840
GO
: GO:0035663
7.

Toll-like receptor 4 binding

Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. Synonym: TLR4 binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
504839
GO
: GO:0035662
8.

positive regulation of toll-like receptor 4 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. Synonyms: positive regulation of TLR4 signaling pathway; positive regulation of toll-like receptor 4 signalling pathway;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
503351
GO
: GO:0034145
9.

positive regulation of toll-like receptor 2 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway. Synonyms: positive regulation of TLR2 signaling pathway; positive regulation of toll-like receptor 2 signalling pathway;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
503343
GO
: GO:0034137
10.

positive regulation of tumor necrosis factor production

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production. Synonyms: activation of tumor necrosis factor production; positive regulation of TNF production; positive regulation of TNF-alpha production; positive regulation of tumor necrosis...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501986
GO
: GO:0032760
11.

protein binding, bridging

The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. Synonym: protein-protein...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
489299
GO
: GO:0030674
12.

MyD88-dependent toll-like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
488628
GO
: GO:0002755
13.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). Synonyms: GO:0045308; alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486730
GO
: GO:0005515

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