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Results: 8

1.

BRCA1-A complex

A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
515461
GO
: GO:0070531
2.

K63-linked polyubiquitin binding

Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
515460
GO
: GO:0070530
3.

positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair. Synonyms: activation of DNA repair; stimulation of DNA repair; up regulation of DNA repair; up-regulation of DNA repair; upregulation of DNA repair;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
508080
GO
: GO:0045739
4.

G2 DNA damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. Synonym: G2/M transition DNA damage checkpoint;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
500823
GO
: GO:0031572
5.

response to ionizing radiation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
494289
GO
: GO:0010212
6.

double-strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
491261
GO
: GO:0006302
7.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490701
GO
: GO:0005634
8.

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
489287
GO
: GO:0042393

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