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Results: 9

1.

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. Synonyms: GO:0010552; GO:0045817; activation of global transcription from RNA polymerase II promoter; activation of transcription from RNA polymerase II promoter;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
508249
GO
: GO:0045944
2.

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. Synonym: sequence specific DNA binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
506596
GO
: GO:0043565
3.

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. Synonyms: down regulation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
505338
GO
: GO:0042177
4.

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. Synonyms: down regulation of proteasomal ubiquitin-dependent...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501667
GO
: GO:0032435
5.

positive regulation of hh target transcription factor activity

Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
492023
GO
: GO:0007228
6.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). Synonyms: GO:0045308; alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486730
GO
: GO:0005515
7.

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. Synonyms: GO:0010553; GO:0045816; down regulation of global transcription from RNA polymerase II promoter; down regulation of transcription from RNA polymerase...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486661
GO
: GO:0000122
8.

Degradation of GLI2 by the proteasome

The primary role of the GLI2 protein is as an activator of Hh-dependent signaling upon pathway stimulation; in the absence of Hh ligand, a small fraction of GLI2 appears to be processed to a repressor form, but the bulk of the protein is completely degraded by the proteasome (reviewed...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Hedgehog signaling events mediated by Gli proteins

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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