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gene silencing by miRNA

Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortgening and subsequent degredation of the mRNA. Synonyms: gene silencing by microRNA; miRNA-mediated gene silencing; microRNA-mediated gene silencing;

from GO source record: GO:0035195
Type: pathway
Taxonomic scope
conserved biosystem

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