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    Lysosome

    Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.

    Type
    :
    pathway
    Taxonomic scope
    :
    conserved biosystem
    BSID:
    96865
    KEGG
    : ko04142



    BioSystem Help


    ASN.1XMLJSONBioSystem Help

    Proteins Genes Compounds PubMed

      Supplemental Content

      Related information

      • Sequences
        • Gene (all)
          Genes contained in the BioSystem
        • Proteins
          Proteins involved in biosystems. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • Nucleotides
          Nucleotides
        • Conserved Domains
          Conserved domains that are specific hits to the proteins involved in biosystems, representing high confidence functional annotations. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • Homologene
          HomoloGene records that are linked to the proteins involved in the biosystem. The HomoloGene records list putative orthologs of the genes that coded the proteins. The association between proteins and biosystems was made using the method descibed in the data processing section of the BioSystems help document.
      • Small molecules
        • PubChem Compounds
          Compounds involved in biosystems. The association between the compounds and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • PubChem Substances
          Substances involved in biosystems. The association between the substances and biosystems was made using the method described in the data processing section of the BioSystems help document.
      • Literature
        • OMIM
          Records from the Online Mendelian Inheritance in Man (OMIM) database that are linked to the Entrez Gene records associated with a BioSystem. The association between genes and biosystems was made using the method descibed in the data processing section of the BioSystems help document.
        • PubMed
          PubMed articles describing biosystems. These are PubMed records whose PMIDs were explicitly cited in the source database biosystem record.
      • Related BioSystems
        • Linked BioSystems
          Biosystems that the source database has explicitly stated are connected in some way.
        • Organism Specific BioSystems
          The organism specific biosystems that correspond to a conserved biosystem, as determined by the source database.
      • Other links
        • BioAssays via Actives
          BioAssays in which compounds from biosystems have been found to be active. The association between the compounds and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • BioAssays via Target
          BioAssays whose protein targets are involved in biosystems. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • Structures
          3D macromolecular structures of proteins involved in biosystems. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.

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