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    p53 signaling pathway

    p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.

    Type
    :
    pathway
    Taxonomic scope
    :
    organism-specific biosystem
    Organism
    :
    Sus scrofa
    BSID:
    84467
    KEGG
    : ssc04115



    BioSystem Help


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    Proteins PubMed

      Supplemental Content

      Related information

      • Sequences
        • Gene (all)
          Genes contained in the BioSystem
        • Proteins
          Proteins involved in biosystems. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.
        • Nucleotides
          Nucleotides
        • Conserved Domains
          Conserved domains that are specific hits to the proteins involved in biosystems, representing high confidence functional annotations. The association between the proteins and biosystems was made using the method described in the data processing section of the BioSystems help document.
      • Literature
        • PubMed
          PubMed articles describing biosystems. These are PubMed records whose PMIDs were explicitly cited in the source database biosystem record.
      • Related BioSystems
        • Conserved BioSystems
          The conserved biosystem, if one is available, that corresponds to an organism specific biosystem. Conserved biosystems are canonical biosystems that are used to group together orthologous, organism specific biosystems.
        • Similar BioSystems
          Biosystems share at least one identical protein sequence from the same source organism. In other words, the shared protein is in the same protein identity group ("PIG," a group of proteins that are identical in sequence) and has the same Taxonomy ID.
        • Linked BioSystems
          Biosystems that the source database has explicitly stated are connected in some way.
      • Other links
        • Taxonomy
          The source organisms of the biosytems, whose Taxonomy IDs were provided in the biosystem records deposited by the source database. For additional information, see the data processing/taxonomy section of the BioSystems help document.

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