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TNF-alpha/NF-kB Signaling Pathway

"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor superfamily. Activation by the homotrimeric ligand results in receptor trimerization. TNFRSF1A trimers result in the activation of NF-kB through MAPK and caspase pathways leading to apoptosis, whereas a heterocomplex of both TNFRSF1A and TNFRSF1B recruits proteins such as BIRC2 and BIRC3, which are apoptotic inhibitors. As both TNF alpha and IL-1 stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity." Source: http://www.netpath.org/pathways?path_id=NetPath_9

from WikiPathways source record: WP231
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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