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Accession: PRJNA132611 ID: 132611

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation (human)

See Genome Information for Homo sapiens
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. More...
Project Data Type:Other
Attributes:Scope: Multiisolate; Material: Other; Capture: Whole; Method type: Array
Relevance:Medical
Other Accessions:GEO:GSE24505
Project Data:
Resource NameNumber
of Links
Publications
PubMed2
PMC2
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots23471742
Data volume, Processed Mbytes674
Data volume, Supplementary Mbytes7007
Publications:
  • Gönen M et al., "CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900.", Blood, 2012 Aug 1;120(11):2297-306
  • Figueroa ME et al., "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.", Cancer Cell, 2010 Dec 9;18(6):553-67
Submission:
Registration date: 4-Oct-2010
Maria Figueroa, Pathology, University of Michigan

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