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Accession: PRJNA141309 ID: 141309

Toxicogenomic Study of Pentamethylchromanol (PMCol) (Norway rat)

See Genome Information for Rattus norvegicus
The objective of this study is to determine the molecular mechanisms of PMCol-induced hapatotoxicity using microarray The study demonstrated that chronic exposure to high doses of PMCol induces liver damage and dysfunction, probably due to both inhibition of synthesis and depletion of liver glutathione as well as modification of other drug metabolism pathways. More...
Project Data Type:Transcriptome or Gene expression
Attributes:Scope: Multiisolate; Material: Transcriptome; Capture: Whole; Method type: Array
Relevance:Model Organism
Other Accessions:GEO:GSE29673
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots792918
Data volume, Processed Mbytes16
Data volume, Supplementary Mbytes122
Publications:
  • Parman T et al., "Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity.", Toxicol Sci, 2011 Sep 13;124(2):487-501
Submission:
Registration date: 1-Nov-2011
SRI International

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