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Accession: PRJNA110593 ID: 110593

Small molecule inhibitors of HIF-2a translation link its 5’-UTR Iron-Responsive Element (IRE) to oxygen sensing (human)

See Genome Information for Homo sapiens
Cells transiently adapt to hypoxia by globally decreasing protein translation. More...
Project Type:Transcriptome or Gene expression
Attributes:Scope: Multiisolate; Material: Transcriptome; Capture: Whole; Method type: Array
Relevance:Medical
Other Accessions:GEO:GSE13818
Project Data:
Resource NameNumber
of Links
Publications
PubMed2
PMC2
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots1421554
Data volume, Processed Mbytes28
Data volume, Supplementary Mbytes127
Publications:
  • Zimmer M et al., "The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.", Cancer Res, 2010 Mar 30;70(8):3071-9
  • Zimmer M et al., "Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.", Mol Cell, 2008 Dec 26;32(6):838-48
Submission:
Registration date: 1-Jan-2009
Cancer Genetics, Cancer Center, Massachusetts General Hospital

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