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Accession: PRJNA74955 ID: 74955

Homo sapiens (human)

The Effect of Crohn's Disease Risk Alleles on Enteric Microbiota

See Genome Information for Homo sapiens
This UH2/UH3 demonstration project entitled "Effects of Crohn's disease risk alleles on enteric microbiota" is focused on characterizing intestinal associated microbiota in patients with ileal Crohn's disease (ileal CD), ulcerative colitis (UC) and control patients without inflammatory bowel diseases (non-IBD). We hypothesize that genetic factors that affect Paneth cell function, contribute to compositional changes in intestinal microbiota. These changes in microbiota may lead to reduction of protective commensal organisms and increased numbers of aggressive organisms that incite intestinal inflammation. This hypothesis is being tested by high throughput 16S rRNA sequence analysis of de-identified ileal and colonic tissues that have been archived at Washington University St. More...
Project Type:Umbrella project, Phenotype or Genotype (Subtype:Authorized Access)
Relevance:Medical
Other Accessions:dbGaP:phs000255
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments12
Capillary Traces (Trace Archive)1
Other datasets
BioSample294
Genotype and Phenotype (dbGaP)1
SRA Data Details
ParameterValue
Data volume, Gbases2
Data volume, Mbytes4147
Homo sapiens encompasses the following sub-project:
Project TypeNumber of Projects
Targeted Locus (Loci)1
BioProject
accession
OrganismTitle
PRJNA46323human metagenomeEffect of Crohn's Disease Risk Alleles on Enteric Microbiota (Washington University)

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    Homo sapiens
    The Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
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