In the last issue of the NCBI newsletter, we reported the release of the 1000th virus RefSeq genome but we did not identify the lucky sequence. The sequence is segment 12 of the complete genome of the Eyach virus. Clicking on the “Nucleotide” link at the top right-hand corner of the Entrez Genomes report for NC_003707.1, the accession number of segment 12, will display all of the segments for this virus genome.

The Eyach virus belongs to the family Reoviridae and to the genus Coltivirus. Viruses of this family contain dsRNA genomes that are divided into segments. The Eyach virus, which has 12 segments, has been linked to neurological disease associated with tick-borne infections in humans. It is antigenically similar to the well-known Colorado tick fever virus. The associated literature citation, accessible via the “PubMed” link, includes comparisons of genomic and morphological data of the Eyach virus to the Colorado tick fever virus, and to other reoviruses, and delineates an evolutionary relationship among these viral groups. Genomic analy-sis of these virus genomes could lead to breakthroughs in deciphering the mechanisms of infection and disease.

For more information on this virus, visit the Virus RefSeq Genomes Web site in Entrez Genomes at www.ncbi.nlm.nih.gov/PMGifs/Genomes/viruses.html. —VP

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