How can I determine what general class of protein I have from its
Aside from running a standard BLAST search NCBI offers two
ways to do this. You can perform a Conserved Domain Database Search
using your protein sequence. From the Structure page (www.ncbi.nlm.nih.gov/Structure)
You can also perform a search against the Clusters of Orthologous
Groups (COGs) a database containing 21 complete proteomes.
From the COGs page (www.ncbi.nlm.nih.gov/COG)
How can I see all the LocusLink entries for human chromosome 22?
From the NCBI home page select the human Map Viewer
then select chromosome 22. In the sidebar of the chromosome 22 map
click on the Chr.22 Resource link which leads to a summary
page with additional information about the chromosome. In the sidebar
of the resource page click on LocusLink Chr.22 Loci.
How can I see all the UniGene Clusters mapping to chromosome 22?
From the chromosome 22 resource page mentioned in the previous question
click on the UniGene Chr.22 Clusters link.
How can I set up a search using the PubMed Cubbyso that
I can retrieve only papers published since my last search?
You first need to register as a Cubby user. From PubMed click
on Cubby in the sidebar and follow the onscreen instructions.
To store a search first run it as usual within PubMed
then click the Cubby link from the sidebar and login to Cubby
as prompted. Your current search will be displayed; press the Store
in Cubby button to add it to your stored search list. To collect
any new material select the search of interest and press the
Whats New for Selected button.
What classes of genetic variation are included in the dbSNP database?
The database accepts several classes of genetic variation including
SNPs microsatellite repeats and small insertion/deletion
polymorphisms. The scope of dbSNP includes disease-causing clinical
mutations as well as neutral polymorphisms.