Complement component 8, alpha polypeptide (C8A)

Restricted Expression:

liver [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

liver; mixed; uncharacterized tissue; blood; lung; spleen

NCBI

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UGID:141547 UniGene Hs.93210 Homo sapiens (human) C8A

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Complement component 8, alpha polypeptide (C8A)

Human protein-coding gene C8A. Represented by 53 ESTs from 21 cDNA libraries. EST representation biased toward liver. Corresponds to reference sequence NM_000562.2. [UniGene 141547 - Hs.93210]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_000553.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	C8A gene product	H. sapiens	100.0	583
NP_666260.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	C8a gene product	M. musculus	78.5	586
NP_001085549.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	complement component 8, alpha polypeptide precursor	X. laevis	57.1	556
NP_001003496.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	c8a gene product	D. rerio	46.1	476
Other hits (2 of 21) [Show all]		Species	Id(%)	Len(aa)
XP_513435.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: complement component C8 alpha chain	P. troglodytes	99.5	583
XP_001114403.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: complement component C8 alpha chain-like	M. mulatta	95.5	583

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	1
Map position:	1p32
UniSTS entry:	Chr 1	RH17669
UniSTS entry:	Chr 1	D1S3432	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

NM_000562.2	Homo sapiens complement component 8, alpha polypeptide (C8A), mRNA	P
M16974.1	Human complement protein C8 alpha subunit mRNA, complete cds	PA
BC132913.1	Homo sapiens complement component 8, alpha polypeptide, mRNA (cDNA clone MGC:164544 IMAGE:40146935), complete cds	P
BC132911.1	Homo sapiens complement component 8, alpha polypeptide, mRNA (cDNA clone MGC:164542 IMAGE:40146933), complete cds	P
AK309596.1	Homo sapiens cDNA, FLJ99637	P
BC020702.1	Homo sapiens complement component 8, alpha polypeptide, mRNA (cDNA clone IMAGE:4714726), partial cds	PA

EST sequences (53)

AI051231.1	Clone IMAGE:1673090	mixed	3' read	A
BX114250.1	Clone IMAGp998P11975_;_IMAGE:416890	mixed		PA
CB153899.1	Clone L17N670205-8-F05	liver	5' read
CB154169.1	Clone L17N670205-4-E07	liver	5' read	P
CB162063.1	Clone L17N670205n1-16-G11	liver	5' read
CB162713.1	Clone L17N670205n1-30-D12	liver	5' read	P
CB164686.1	Clone L17N670205n1-43-C09	liver	5' read	P
BX346132.2	Clone CS0DJ010YK19	blood	3' read	P
BX346133.2	Clone CS0DJ010YK19	blood	5' read	P
BX370270.1	Clone CS0DJ002YJ10	blood	5' read	P
BX382940.2	Clone CS0DJ002YJ10	blood	5' read	P
CD366989.1	Clone UI-H-FT2-bjp-b-13-0-UI	lung	3' read	PA
BX494600.1	Clone DKFZp779I0514	liver	5' read	P
CD609019.1		uncharacterized tissue
CD609020.1		uncharacterized tissue
CD609021.1		uncharacterized tissue
CD609022.1		uncharacterized tissue
AW963046.1		uncharacterized tissue		P
AW963056.1		uncharacterized tissue		P
AV650069.1	Clone GLCCAH12	liver	3' read	P
AV658742.1	Clone GLCFPF10	liver	3' read	P
AV691228.1	Clone GKCANE10	liver	5' read	P
AV692569.1	Clone GKCCNB07	liver	5' read	P
AV693235.1	Clone GKCAOC09	liver	5' read	P
AV698336.1	Clone GKCGED06	liver	5' read
AV698708.1	Clone GKCAMA12	liver	5' read	P
AV698840.2	Clone GKCALE04	liver	5' read	P
DR004048.1	Clone TC119839	liver	5' read	P
T28622.1		liver	3' read	A
BF126691.1	Clone IMAGE:4071712	liver	5' read	P
H53865.1	Clone IMAGE:202682	mixed	3' read	A
DA640260.1	Clone LIVER2005013	liver	5' read	P
DB321283.1	Clone LIVER2004073	liver	3' read	PA
BG563768.1	Clone IMAGE:4712316	liver	5' read	P
BG564128.1	Clone IMAGE:4714726	liver	5' read	P
BG567002.1	Clone IMAGE:4723442	liver	5' read
BJ996340.1	Clone hyst-1143	liver	5' read	P
N93779.1	Clone IMAGE:308386	lung	3' read	A
T51706.1	Clone IMAGE:72476	spleen	5' read
T51917.1	Clone IMAGE:72476	spleen	3' read	A
W86807.1	Clone IMAGE:416890	mixed	3' read	A
W87334.1	Clone IMAGE:416890	mixed	5' read
T68733.1	Clone IMAGE:82106	liver	3' read
T68983.1	Clone IMAGE:82257	liver	3' read
T68989.1	Clone IMAGE:82280	liver	3' read
T69060.1	Clone IMAGE:82257	liver	5' read
T69068.1	Clone IMAGE:82280	liver	5' read
T69692.1	Clone IMAGE:83573	liver	5' read
BU942533.1	Clone IMAGE:6715524	mixed	5' read	P
AA343585.1		liver	5' read	P
AA343878.1		liver	5' read	P
AA344521.1		liver	5' read	P
AA699772.1	Clone IMAGE:461342	mixed	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria