> Sphingosine kinase 1 (SPHK1)
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UGID:139253     UniGene Hs.68061     Homo sapiens (human)   SPHK1 Order cDNA clone, Links
Sphingosine kinase 1 (SPHK1)

Human protein-coding gene SPHK1. Represented by 203 ESTs from 107 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 139253 - Hs.68061]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_892010.2 SPHK1 gene product H. sapiens 100.0 469
XP_003953242.1 PREDICTED: sphingosine kinase 1 isoform 2 P. troglodytes 100.0 397
NP_079643.2 Sphk1 gene product M. musculus 86.4 381
XP_002667585.2 PREDICTED: sphingosine kinase 1-like D. rerio 60.2 334
NP_001088560.1 sphingosine kinase 1 X. laevis 57.1 396
Other hits (2 of 22) [Show all]SpeciesId(%)Len(aa)
XP_003913526.1 PREDICTED: sphingosine kinase 1 isoform 2 P. anubis 98.3 469
XP_001099066.2 PREDICTED: sphingosine kinase 1-like M. mulatta 97.6 458

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: skin; brain; lung; uncharacterized tissue; mixed; intestine; ovary; vascular; embryonic tissue; pancreas; spleen; mammary gland; cervix; liver; bladder; bone marrow; connective tissue; prostate; heart; esophagus; mouth; testis; thymus; bone; kidney; blood; eye; thyroid; placenta; uterus; larynx; stomach; ascites; salivary gland; ganglia; umbilical cord; trachea
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q25.2
UniSTS entry: Chr 17 RH47748 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (21)

AK122781.1 Homo sapiens cDNA FLJ16332 fis, clone SYNOV2016837, highly similar to Sphingosine kinase 1 (EC 2.7.1.-) P
NM_182965.2 Homo sapiens sphingosine kinase 1 (SPHK1), transcript variant 2, mRNA PA
AJ245504.1 Homo sapiens mRNA for sphingosine kinase (gene SPK) PA
AF238083.1 Homo sapiens sphingosine kinase-1 mRNA, complete cds PA
AF266756.1 Homo sapiens sphingosine kinase (SPHK1) mRNA, complete cds P
AK022402.1 Homo sapiens cDNA FLJ12340 fis, clone MAMMA1002268, moderately similar to Mus musculus sphingosine kinase (SPHK1a) mRNA P
AK023393.1 Homo sapiens cDNA FLJ13331 fis, clone OVARC1001809, moderately similar to Mus musculus sphingosine kinase (SPHK1a) mRNA P
AF200328.1 Homo sapiens sphingosine kinase (SPHK) mRNA, complete cds P
NM_021972.3 Homo sapiens sphingosine kinase 1 (SPHK1), transcript variant 1, mRNA PA
AK225258.1 Homo sapiens mRNA for sphingosine kinase 1 isoform 1 variant, clone: DMC03040 PA
AK225250.1 Homo sapiens mRNA for sphingosine kinase 1 isoform 2 variant, clone: DMC02610 PA
BC004112.2 Homo sapiens sphingosine kinase 1, mRNA (cDNA clone IMAGE:3832587), partial cds PA
BC008040.2 Homo sapiens sphingosine kinase 1, mRNA (cDNA clone MGC:15041 IMAGE:3831657), complete cds PA
BC009419.1 Homo sapiens sphingosine kinase 1, mRNA (cDNA clone MGC:15040 IMAGE:3506924), complete cds PA
AK292614.1 Homo sapiens cDNA FLJ78254 complete cds PA
AK292294.1 Homo sapiens cDNA FLJ77593 complete cds, highly similar to Homo sapiens sphingosine kinase 1 (SPHK1), transcript variant 2, mRNA P
AK095578.1 Homo sapiens cDNA FLJ38259 fis, clone FCBBF3001302, highly similar to Homo sapiens sphingosine kinase (SPHK1) mRNA P
BC014439.1 Homo sapiens sphingosine kinase 1, mRNA (cDNA clone MGC:22956 IMAGE:4871343), complete cds PA
BC030553.1 Homo sapiens sphingosine kinase 1, mRNA (cDNA clone MGC:40267 IMAGE:5213270), complete cds PA
NM_001142602.1 Homo sapiens sphingosine kinase 1 (SPHK1), transcript variant 4, mRNA PA
NM_001142601.1 Homo sapiens sphingosine kinase 1 (SPHK1), transcript variant 3, mRNA PA

EST sequences (203)

AI042283.1 Clone IMAGE:1665736 skin 3' read A
AI074186.1 Clone IMAGE:1681960 skin 3' read A
BX106465.1 Clone IMAGp998C174228_;_IMAGE:1665736 skin P
CB155672.1 Clone B2N807043-11-D02 brain 5' read
AI341901.1 Clone IMAGE:1946069 uncharacterized tissue 3' read A
AI769914.1 Clone IMAGE:2404331 kidney 3' read PA
BX398861.2 Clone CS0DI065YH09 placenta 5' read P
BX398860.2 Clone CS0DI065YH09 placenta 3' read P
AI873962.1 Clone IMAGE:2438641 uterus 3' read A
BX362837.1 Clone CS0DK004YP21 cervix 3' read P
BX362838.2 Clone CS0DK004YP21 cervix 5' read P
BX363407.2 Clone CS0DK012YL15 cervix 3' read P
BX363408.2 Clone CS0DK012YL15 cervix 5' read P
BX401290.2 Clone CS0DK011YD19 cervix 3' read P
BX401291.2 Clone CS0DK011YD19 cervix 5' read P
BX419666.2 Clone CS0DF019YG08 brain 5' read
AI972156.1 Clone IMAGE:2492360 uterus 3' read PA
CD366097.1 Clone UI-H-FT1-bjs-j-17-0-UI lung 3' read PA
CD369198.1 Clone UI-H-FT1-bjy-m-16-0-UI lung 3' read PA
CD523021.1 Clone IMAGE:30409951 blood 5' read
CD518980.1 Clone IMAGE:30398514 brain 5' read P
CD676171.1 Clone fs33a03 eye 5' read P
CD723434.1 Clone oj22b08 eye 5' read A
CD723469.1 Clone oj22f02 eye 5' read A
AW192475.1 Clone IMAGE:2677587 pancreas 3' read A
AW581387.1 uncharacterized tissue
AW662445.1 Clone IMAGE:2973512 intestine 3' read PA
AW963415.1 uncharacterized tissue P
CN398413.1 embryonic tissue 5' read P
CN398414.1 embryonic tissue 5' read
CN398415.1 embryonic tissue 5' read PA
CN398416.1 embryonic tissue 5' read P
CN398417.1 embryonic tissue 5' read P
BE145317.1 mouth P
CV027223.1 mixed 5' read P
CV028128.1 mixed 5' read P
BE273426.1 Clone IMAGE:3506924 kidney 5' read P
BE274434.1 Clone IMAGE:2967353 skin 5' read P
BP226452.1 Clone DMC02610 uncharacterized tissue 5' read P
BP226574.1 Clone DMC03040 uncharacterized tissue 5' read P
BP226757.1 Clone DMC03609 uncharacterized tissue 5' read P
BE275818.1 Clone IMAGE:3346011 skin 5' read P
BP304783.1 Clone MPG02562 uncharacterized tissue 5' read P
BP364701.1 Clone TIR04817 lung 5' read P
BP365279.1 Clone TIR06359 lung 5' read P
BP267514.1 Clone JTH07268 thyroid 5' read P
BP267668.1 Clone JTH07674 thyroid 5' read P
BP268126.1 Clone JTH09053 thyroid 5' read P
BP269223.1 Clone JTH12811 thyroid 5' read P
BP272490.1 Clone KAT04964 stomach 5' read P
BE464487.1 Clone IMAGE:3208290 uncharacterized tissue 3' read PA
BE727208.1 Clone IMAGE:3832587 skin 5' read
BE728564.1 Clone IMAGE:3831657 skin 5' read P
BE740866.1 Clone IMAGE:3947182 ovary 5' read P
AV694791.1 Clone GKCEEE05 liver 5' read P
DN999917.1 Clone TC121602 vascular 5' read P
DR006729.1 Clone TC112836 spleen 5' read P
BE891653.1 Clone IMAGE:3919548 skin 5' read P
BE904632.1 Clone IMAGE:3900609 pancreas 5' read P
AV731866.1 Clone HTFBPG11 brain 5' read
AU122376.1 Clone MAMMA1002268 mammary gland 5' read P
AU134361.1 Clone OVARC1001809 ovary 5' read P
BY796242.2 Clone HE1301.seq eye 5' read P
DA005833.1 Clone 3NB692007048 uncharacterized tissue 5' read
DA157769.1 Clone BRAMY2017192 brain 5' read
DA027266.1 Clone ASTRO2010690 brain 5' read P
DA042067.1 Clone BLADE2003656 bladder 5' read
DA646496.1 Clone MAMMA1001300 mammary gland 5' read
DA385396.1 Clone BRTHA2020347 brain 5' read P
DA581916.1 Clone HLUNG2001074 lung 5' read
DA543207.1 Clone HCASM2000553 vascular 5' read
DA577432.1 Clone HHDPC2005157 skin 5' read
DA544435.1 Clone HCASM2002004 vascular 5' read
DA578198.1 Clone HHDPC2006158 skin 5' read P
DA579978.1 Clone HHDPC2008396 skin 5' read P
DA508878.1 Clone FCBBF3025266 brain 5' read
DA482243.1 Clone ERLTF2001698 bone marrow 5' read P
DA371155.1 Clone BRTHA2000940 brain 5' read
DA588594.1 Clone HLUNG2010059 lung 5' read
DA600531.1 Clone HSYRA2005626 connective tissue 5' read P
DA589046.1 Clone HLUNG2010617 lung 5' read
DA490150.1 Clone FCBBF3001302 brain 5' read
DA602056.1 Clone HSYRA2007634 connective tissue 5' read
DA563342.1 Clone HEART2005174 heart 5' read P
DA446229.1 Clone CTONG2017129 mouth 5' read
DA375269.1 Clone BRTHA2006490 brain 5' read
DA447983.1 Clone CTONG2019525 mouth 5' read
DA599615.1 Clone HSYRA2004497 connective tissue 5' read P
AU147968.1 Clone MAMMA1002268 mammary gland 3' read A
DA645631.1 Clone MAMGL1000010 mammary gland 5' read P
DA462974.1 Clone D3OST2000390 uncharacterized tissue 5' read P
DA580222.1 Clone HHDPC2008695 skin 5' read
DA869663.1 Clone PROST2005524 prostate 5' read P
DA908570.1 Clone SKNSH2000808 brain 5' read
DA882947.1 Clone PUAEN2002570 vascular 5' read
DA883304.1 Clone PUAEN2002999 vascular 5' read
DA883465.1 Clone PUAEN2003185 vascular 5' read
DA884768.1 Clone PUAEN2004692 vascular 5' read
DA918167.1 Clone SMINT2003002 intestine 5' read P
DA846306.1 Clone PLACE6014723 placenta 5' read P
DA999679.1 Clone TBAES2001169 mammary gland 5' read
DB014198.1 Clone TESOP2002938 esophagus 5' read P
DB018514.1 Clone TESOP2008324 esophagus 5' read P
DB018860.1 Clone TESOP2008752 esophagus 5' read P
DA872428.1 Clone PROST2009343 prostate 5' read
DB032569.1 Clone TESTI2017036 testis 5' read P
DA873944.1 Clone PROST2011344 prostate 5' read P
DA953057.1 Clone SPLEN2030877 spleen 5' read
DB107146.1 Clone THYMU2008864 thymus 5' read P
DB160583.1 Clone THYMU3040803 thymus 5' read
DB154563.1 Clone THYMU3032594 thymus 5' read
DB130111.1 Clone THYMU2040638 thymus 5' read P
BF741980.1 thyroid
DB321428.1 Clone MAMGL1000010 mammary gland 3' read A
DB321456.1 Clone MAMGL1000042 mammary gland 3' read A
DB315360.1 Clone FCBBF3001302 brain 3' read PA
DB198704.1 Clone TRACH2006763 trachea 5' read P
DB361183.1 Clone MAMMA1001300 mammary gland 3' read PA
BF748455.1 mammary gland
DB140236.1 Clone THYMU3013165 thymus 5' read
DB174389.1 Clone TKIDN2010249 kidney 5' read
DB255215.1 Clone UTERU2010448 uterus 5' read
DB255860.1 Clone UTERU2011367 uterus 5' read
DB295013.1 Clone 3NB692007048 uncharacterized tissue 3' read PA
DB334898.1 Clone SYNOV2016837 connective tissue 3' read PA
BG104264.1 Clone IMAGE:4423139 skin 5' read P
BG112624.1 Clone IMAGE:4370150 bone 5' read
BG026631.1 Clone IMAGE:4388511 bone 5' read P
BF983966.1 Clone IMAGE:4395926 intestine 5' read
BF930311.1 brain
BG280830.1 Clone IMAGE:4543395 skin 5' read P
BG325513.1 Clone IMAGE:4562282 kidney 5' read
BG500754.1 Clone IMAGE:4669481 prostate 5' read P
D31133.1 lung 5' read P
BG678689.1 Clone IMAGE:4749573 skin 5' read P
BG680521.1 Clone IMAGE:4753187 skin 5' read P
BG766076.1 Clone IMAGE:4863782 skin 5' read
BG767523.1 Clone IMAGE:4871343 skin 5' read
BG987849.1 larynx
BI004930.1 thyroid
BI005373.1 thyroid P
BI013436.1 lung P
BI013566.1 lung P
EL733682.1 mixed 5' read P
EL735233.1 mixed 5' read P
ES307468.1 skin 5' read
BI255900.1 Clone IMAGE:5115605 cervix 5' read P
DC358422.1 Clone HLUNG2004031 lung 5' read
DC300370.1 Clone ASTRO2019062 brain 5' read
DC404745.1 Clone THYMU2001732 thymus 5' read P
DC393972.1 Clone TESOP2002699 esophagus 5' read P
DC384776.1 Clone PUAEN2005435 vascular 5' read P
BI757316.1 Clone IMAGE:5199943 brain 5' read P
BI823329.1 Clone IMAGE:5182305 mixed 5' read P
BI860351.1 Clone IMAGE:5396178 mammary gland 5' read P
BI911482.1 Clone IMAGE:5213270 blood 5' read P
BI912225.1 Clone IMAGE:5217439 blood 5' read
BM006005.1 Clone IMAGE:5433632 liver 5' read P
BM471402.1 Clone IMAGE:5563187 skin 5' read A
BM471470.1 Clone IMAGE:5563230 skin 5' read A
BM549624.1 Clone IMAGE:5745716 blood 5' read
BM550039.1 Clone IMAGE:5745953 blood 5' read P
BM556915.1 Clone IMAGE:5467608 skin 5' read P
BM557357.1 Clone IMAGE:5466709 skin 5' read P
BM559257.1 Clone IMAGE:5474413 skin 5' read P
BM706865.1 Clone UI-E-CQ0-adu-g-07-0-UI brain 5' read
BM709951.1 Clone UI-E-CK1-agb-p-20-0-UI eye 5' read P
BM808666.1 Clone IMAGE:5471294 skin 5' read P
BM808698.1 Clone IMAGE:5471258 skin 5' read P
BM808932.1 Clone IMAGE:5471472 skin 5' read P
BM810136.1 Clone IMAGE:5470089 skin 5' read P
BM810752.1 Clone IMAGE:5473096 skin 5' read P
W63556.1 Clone IMAGE:326250 skin 5' read
BM797761.1 Clone S22SNU16n1-79-C01 ascites 5' read P
BM832647.1 Clone S11SNU1-47-H06 ascites 5' read
BM911938.1 Clone IMAGE:5471107 skin 5' read
BM916526.1 Clone IMAGE:5482958 skin 5' read P
BQ027486.1 Clone IMAGE:3105241 uncharacterized tissue 3' read A
BQ109456.1 Clone IMAGE:5217439 blood 5' read P
BQ355058.1 larynx
AA026479.1 Clone IMAGE:469133 uterus 5' read
BQ647377.1 Clone IMAGE:6272071 liver 5' read P
BQ675531.1 Clone IMAGE:6256195 salivary gland 5' read P
BG057227.1 Clone IMAGE:3302771 ganglia 3' read A
BU158134.1 Clone IMAGE:6254342 salivary gland 5' read P
AA081127.1 Clone IMAGE:549298 umbilical cord 3' read A
AA081152.1 Clone IMAGE:549298 umbilical cord 5' read P
BU626812.1 Clone UI-H-FT0-bhl-d-18-0-UI lung 3' read PA
BU630558.1 Clone UI-H-FL0-bdk-d-23-0-UI bone 3' read PA
BU617770.1 Clone UI-H-DF0-bew-k-09-0-UI bone 3' read PA
BU728196.1 Clone UI-E-CQ0-adu-g-06-0-UI brain 3' read A
BU728197.1 Clone UI-E-CQ0-adu-g-07-0-UI brain 3' read A
AA232646.1 Clone IMAGE:666375 mixed 3' read A
AA232791.1 Clone IMAGE:666375 mixed 5' read
BU736749.1 Clone UI-E-CK1-agb-p-20-0-UI eye 3' read PA
HY034312.1 Clone H04D118J09 testis
HY219111.1 Clone H04D118J09 testis
CA307119.1 Clone UI-H-FT1-bhu-j-07-0-UI lung 3' read PA
CA308953.1 Clone UI-H-FT1-bhz-e-03-0-UI lung 3' read PA
CA420750.1 Clone UI-H-FG0-bcq-f-05-0-UI bone 3' read PA
AA372241.1 eye 5' read
AA372249.1 eye 5' read
AA639414.1 Clone IMAGE:1159486 intestine 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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