> Tryptophan hydroxylase 1 (TPH1)
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UGID:2061010     UniGene Hs.591999     Homo sapiens (human)   TPH1 Order cDNA clone, Links
Tryptophan hydroxylase 1 (TPH1)

Human protein-coding gene TPH1. Represented by 10 ESTs from 6 cDNA libraries. EST representation biased toward pituitary gland. Corresponds to reference sequence NM_004179.2. [UniGene 2061010 - Hs.591999]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004170.1 TPH1 gene product H. sapiens 100.0 443
XP_521852.3 PREDICTED: tryptophan 5-hydroxylase 1 isoform 4 P. troglodytes 99.6 453
NP_001129556.1 Tph1 gene product M. musculus 89.5 446
NP_001080923.1 tryptophan 5-hydroxylase X. laevis 81.7 464
NP_840091.1 tph1a gene product D. rerio 80.2 429
NP_001014573.1 henna, isoform B D. melanogaster 54.6 423
NP_001254184.1 Protein PAH-1, isoform b C. elegans 53.1 431
XP_001690034.1 aromatic amino acid hydroxylase-related protein C. reinhardtii 46.6 176
Other hits (2 of 43) [Show all]SpeciesId(%)Len(aa)
NP_001184120.1 TPH1 gene product C. lupus familiaris 97.8 443
XP_001505004.1 PREDICTED: tryptophan 5-hydroxylase 1 E. caballus 97.3 443

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: pituitary gland [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; eye; brain; intestine; pituitary gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p15.3-p14
UniSTS entry: Chr 11 GDB:197867
UniSTS entry: Chr 11 TPH
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (5)

AY196346.1 Homo sapiens tryptophan hydroxylase precursor RNA, partial cds P
NM_004179.2 Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA P
BC106739.1 Homo sapiens tryptophan hydroxylase 1, mRNA (cDNA clone MGC:119994 IMAGE:40016887), complete cds P
BC106740.2 Homo sapiens tryptophan hydroxylase 1, mRNA (cDNA clone IMAGE:40016889), complete cds P
X52836.1 Human mRNA for tryptophan hydroxylase (EC 1.14.16.4) P

EST sequences (10)

BX114367.1 Clone IMAGp998G095801_;_IMAGE:2338208 lung A
AI694418.1 Clone IMAGE:2338208 lung 3' read
AI912589.1 Clone IMAGE:2340789 lung 3' read
BE252379.1 Clone IMAGE:3358333 eye 5' read
BE467039.1 Clone IMAGE:3213171 lung 3' read
BE673864.1 Clone IMAGE:3278351 lung 3' read
DN992199.1 Clone TC108521 brain 5' read P
BP423529.1 Clone HIE07087r intestine 3' read P
AV751479.1 Clone NPDAWE07 pituitary gland 5' read
BM451912.1 Clone IMAGE:5492778 eye 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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