ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5)

Restricted Expression:

fetus [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

brain; lung; mixed; adrenal gland; eye; testis; uncharacterized tissue; thyroid; prostate; kidney

NCBI

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Finding cDNAs

UGID:680184 UniGene Hs.465025 Homo sapiens (human) ST8SIA5

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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5)

Human protein-coding gene ST8SIA5. Represented by 49 ESTs from 27 cDNA libraries. EST representation biased toward fetus. Corresponds to reference sequence NM_013305.4. [UniGene 680184 - Hs.465025]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001009087.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	ST8SIA5 gene product	P. troglodytes	100.0	375
NP_037437.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	ST8SIA5 gene product	H. sapiens	100.0	375
NP_001077419.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	ST8SIA5 gene product	M. mulatta	99.7	375
XP_003914397.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: alpha-2,8-sialyltransferase 8E isoform 2	P. anubis	99.5	411
NP_038694.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	St8sia5 gene product	M. musculus	85.0	411
NP_001191083.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	st8sia5 gene product	D. rerio	75.3	409
NP_001083088.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase	X. laevis	50.2	281
Other hits (2 of 18) [Show all]		Species	Id(%)	Len(aa)
NP_001179803.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	alpha-2,8-sialyltransferase 8E	B. taurus	99.2	375
XP_001498735.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: alpha-2,8-sialyltransferase 8E	E. caballus	99.2	372

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	18
Map position:	18q21.1
UniSTS entry:	Chr 18	SIAT8E__6834
UniSTS entry:	Chr 18	WI-13748	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AK130126.1	Homo sapiens cDNA FLJ26616 fis, clone MPB06888, highly similar to Homo sapiens sialyltransferase 8E (alpha-2, 8-polysialyltransferase) (SIAT8E)	P
CR457037.1	Homo sapiens full open reading frame cDNA clone RZPDo834C0218D for gene SIAT8E, sialyltransferase 8E (alpha-2, 8-polysialyltransferase); complete cds, incl. stopcodon	P
NM_013305.4	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5), mRNA	P
BC108910.1	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, mRNA (cDNA clone MGC:119670 IMAGE:40011279), complete cds	P
BC108911.1	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, mRNA (cDNA clone MGC:119671 IMAGE:40011281), complete cds	P
AK056270.1	Homo sapiens cDNA FLJ31708 fis, clone NT2RI2006271, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-)	P
AK310764.1	Homo sapiens cDNA, FLJ17806	P
AK094273.1	Homo sapiens cDNA FLJ36954 fis, clone BRACE2005800, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-)	P
AK298881.1	Homo sapiens cDNA FLJ52727 complete cds, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-)	P
AK293608.1	Homo sapiens cDNA FLJ60231 complete cds, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-)	P
U91641.1	Human alpha2,8-sialyltransferase mRNA, complete cds	P

EST sequences (49)

BX105571.1	Clone IMAGp998M22159_;_IMAGE:34837	brain		A
AI681140.1	Clone IMAGE:2272427	lung	3' read	A
AI689795.1	Clone IMAGE:2270662	lung	3' read	A
AI692935.1	Clone IMAGE:2338792	lung	3' read	A
AI929731.1	Clone IMAGE:2519495	brain	5' read	P
AW087114.1	Clone IMAGE:2519495	brain	3' read	A
AW134945.1	Clone IMAGE:2712733	mixed	3' read	A
AW138675.1	Clone IMAGE:2716309	mixed	3' read	A
AW157019.1	Clone IMAGE:2782765	brain	3' read	A
AW161524.1	Clone IMAGE:2782765	brain	5' read	P
AW162481.1	Clone IMAGE:2781269	brain	3' read	A
AW206911.1	Clone IMAGE:2722924	mixed	3' read	A
AW250347.1	Clone IMAGE:2821987	lung	5' read	P
AW251085.1	Clone IMAGE:2821987	lung	3' read	A
BE041668.1	Clone IMAGE:3039196	lung	3' read	A
BE174853.1		thyroid
BE779688.1	Clone IMAGE:3868417	eye	5' read	P
AV706896.1	Clone ADBBCC02	adrenal gland	5' read
BF111425.1	Clone IMAGE:3523158	mixed	3' read	A
AU130750.1	Clone NT2RP3001373	testis	5' read
DA201978.1	Clone BRAWH2006837	brain	5' read	P
DA012209.1	Clone ADRGL2004380	adrenal gland	5' read	P
DA346648.1	Clone BRSSN2007785	brain	5' read	P
DA088852.1	Clone BRACE2044122	brain	5' read
DA055570.1	Clone BRACE2001636	brain	5' read	P
DA058116.1	Clone BRACE2005800	brain	5' read
DA065030.1	Clone BRACE2014343	brain	5' read	P
DA026859.1	Clone ASTRO2010191	brain	5' read
DA067668.1	Clone BRACE2017613	brain	5' read	P
DA074765.1	Clone BRACE2026353	brain	5' read	P
DA074818.1	Clone BRACE2026438	brain	5' read	P
DA115904.1	Clone BRACE3035076	brain	5' read	P
DA516658.1	Clone FEBRA2005158	brain	5' read	P
DA366057.1	Clone BRSTN2013850	brain	5' read	P
DA680225.1	Clone NHNPC2002675	uncharacterized tissue	5' read
DA684665.1	Clone NT2NE2002344		5' read
DA703200.1	Clone NT2RI2006271		5' read
BF438207.1	Clone IMAGE:3703395	lung	3' read	A
DA871895.1	Clone PROST2008555	prostate	5' read	P
DB296761.1	Clone BRACE2005800	brain	3' read
DB323814.1	Clone NT2RI2006271		3' read	A
DB175782.1	Clone TKIDN2012137	kidney	5' read	P
DB367892.1	Clone NT2RP3001373	testis	3' read
BF968902.1	Clone IMAGE:4358800	adrenal gland	5' read	P
DT219626.1		brain		P
DC366743.1	Clone NT2NE2018797		5' read	P
BM679941.1	Clone UI-E-EO1-aix-a-18-0-UI	eye	3' read	A
BM723736.1	Clone UI-E-EO1-aix-a-18-0-UI	eye	5' read
U55966.1	Clone 34837	uncharacterized tissue	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria