Cyclin-dependent kinase 4 (CDK4)

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UGID:141747 UniGene Hs.95577 Homo sapiens (human) CDK4

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Cyclin-dependent kinase 4 (CDK4)

SELECTED PROTEIN SIMILARITIES

Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.

Reference Protein		Species	Id(%)	Len(aa)
XP_001116412.1	PREDICTED: cyclin-dependent kinase 4 isoform 2	M. mulatta	100.0	302
XP_509173.2	PREDICTED: cyclin-dependent kinase 4	P. troglodytes	100.0	302
NP_000066.1	cyclin-dependent kinase 4	H. sapiens	100.0	302
NP_034000.1	cyclin-dependent kinase 4	M. musculus	97.7	302
NP_001079719.1	hypothetical protein LOC379406	X. laevis	88.2	297
NP_001071245.1	cyclin-dependent kinase 4	D. rerio	84.1	289
NP_477196.1	Cyclin-dependent kinase 4, isoform B	D. melanogaster	57.0	293
XP_001698637.1	cyclin dependent protein kinase	C. reinhardtii	55.9	323
NP_566911.1	CDC2 (CELL DIVISION CONTROL 2); cyclin-dependent protein kinase/ kinase/ protein binding / protein kinase	A. thaliana	55.5	291
XP_330428.1	CELL DIVISION CONTROL PROTEIN 2 (CYCLIN-DEPENDENT PROTEIN KINASE)	N. crassa	53.4	313
NP_009718.1	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; Cdc28p	S. cerevisiae	53.1	292
NP_499783.1	Cyclin-Dependent Kinase family member (cdk-5)	C. elegans	50.7	284

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	muscle; brain; skin; embryonic tissue; uterus; lung; placenta; intestine; liver; uncharacterized tissue; eye; mixed; prostate; ovary; cervix; pancreas; kidney; blood; lymph; mammary gland; testis; larynx; bladder; salivary gland; thymus; esophagus; ascites; stomach; lymph node; bone; thyroid; heart; vascular; bone marrow; connective tissue; adrenal gland; adipose tissue; pharynx; nerve; ganglia; pituitary gland

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	12
Map position:	12q14
UniSTS entry:	Chr 12	D12S1972
UniSTS entry:	Chr 12	STS-M14505
UniSTS entry:	Chr 1	GDB:593068
UniSTS entry:		WI-18835
UniSTS entry:	Chr 12	GDB:384863
UniSTS entry:	Chr 2	D1S1425

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (24)

NM_000075.2	Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA	PA
CR407668.1	Homo sapiens full open reading frame cDNA clone RZPDo834B043D for gene CDK4, cyclin-dependent kinase 4 complete cds, without stopcodon	P
CR542247.1	Homo sapiens full open reading frame cDNA clone RZPDo834A0426D for gene CDK4, cyclin-dependent kinase 4; complete cds, incl. stopcodon	P
CR622282.1	full-length cDNA clone CS0DH006YG18 of T cells (Jurkat cell line) of Homo sapiens (human)	P
CR616342.1	full-length cDNA clone CS0DI077YB14 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR609991.1	full-length cDNA clone CS0DJ013YA22 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human)	P
CR608247.1	full-length cDNA clone CS0DI078YD23 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR602927.1	full-length cDNA clone CS0DH005YN01 of T cells (Jurkat cell line) of Homo sapiens (human)	P
CR602761.1	full-length cDNA clone CS0DL011YD24 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human)	P
CR598582.1	full-length cDNA clone CS0DL004YJ22 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human)	P
CR597992.1	full-length cDNA clone CS0DL001YP14 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human)	P
CR594194.1	full-length cDNA clone CS0DI040YM08 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR591116.1	full-length cDNA clone CS0DI025YN04 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR590586.1	full-length cDNA clone CS0DI052YK15 of Placenta Cot 25-normalized of Homo sapiens (human)	P
BC003644.2	Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:4678 IMAGE:3532812), complete cds	PA
BC005864.2	Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:3719 IMAGE:2961345), complete cds	PA
BC010153.2	Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:19704 IMAGE:3531300), complete cds	PA
BC015669.2	Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone IMAGE:4139521), complete cds	PA
Z48970.1	H.sapiens mRNA (open reading frame; patient SK29(AV))	P
AK313701.1	Homo sapiens cDNA, FLJ94294, highly similar to Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA	P
AK310724.1	Homo sapiens cDNA, FLJ17766	P
AK297901.1	Homo sapiens cDNA FLJ60730 complete cds, highly similar to Cell division protein kinase 4 (EC 2.7.11.22)	P
U79269.1	Human cyclin-dependent protein kinase mRNA, complete cds	PA
M14505.1	Human (clone PSK-J3) cyclin-dependent protein kinase mRNA, complete cds.,	P

EST sequences (10 of 1013) [Show all sequences]

AA862504.1	Clone IMAGE:1457000	kidney	3' read
AA968686.1	Clone IMAGE:1592300	kidney	3' read	P
AA970350.1	Clone IMAGE:1576384	intestine	3' read	P
AA834523.1	Clone IMAGE:1421806	kidney
AI033787.1	Clone IMAGE:1656860	mixed	3' read	P
AI123895.1	Clone IMAGE:1692916	heart	3' read	P
CB045295.1	Clone IMAGE:3218392	intestine	5' read	P
AI087216.1	Clone IMAGE:1679878	skin	3' read	P
AI160342.1	Clone IMAGE:1706362	heart	3' read	P
BX104215.1	Clone IMAGp998B0474_;_IMAGE:23866	brain		PA

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria